1 citations
,
January 2016 in “Methods in molecular biology” This article reviews a new method to accurately estimate proliferative and migratory epithelial cell numbers post-wounding but reports no experimental findings; the authors suggest its relevance to skin stem-cell biology research.
50 citations
,
May 2020 in “FEBS Letters” This review discusses techniques for analyzing the cell cycle, highlighting emerging tools for measuring cell cycle speed at single-cell resolution in live animals, and reports no new results.
52 citations
,
October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
38 citations
,
June 2005 in “Contact Dermatitis” This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.
1 citations
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March 2004 in “Patty's Toxicology” This article reviews the properties, uses, and toxic effects of eleven unsaturated halogenated hydrocarbons, highlighting the risks associated with compounds like dichloroacetylene, allyl chloride, and vinyl chloride, and reports no new experimental findings.
1 citations
,
March 2004 in “Patty's Toxicology” This review discusses the uses and toxicological data of eleven unsaturated halogenated hydrocarbons, including dichloroacetylene, allyl chloride, hexachlorobutadiene, β-chloroprene, vinyl chloride, trichloroethylene, and perchloroethylene, but presents no new findings.
1 citations
,
January 1978 in “PubMed” This study found that certain synthetic corticosteroid and progesterone analogues inhibited hair growth in castrated male mice, with varying effects based on specific chemical modifications.
2 citations
,
May 1985 in “Environmental Health Perspectives” This report examines the mechanisms by which TCDD affects human epidermal and carcinoma cells, aiming to create a risk assessment model for halogenated aromatic compounds, but presents no new clinical results.
May 2024 in “Journal of molecular structure” This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.
This study synthesized new heterocyclic steroid derivatives and reported their promising antiproliferative activity against breast and prostate cancer cell lines, highlighting selectivity and impact on signaling pathways even in cells resistant to certain treatments.
6 citations
,
November 2004 in “Bioorganic & Medicinal Chemistry Letters” This study found that arylhydantoin and arylthiohydantoin derivatives with hydroxybutyl or methyl side-chains showed superior androgen receptor binding affinity and may serve as promising radioiodinated AR ligands.
This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.
20 citations
,
June 2022 in “Molecules” This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.
5 citations
,
June 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that applying topical thymidine dinucleotide (pTT) to newborn mice before UV exposure delayed and reduced melanoma development compared to untreated controls.
54 citations
,
July 1967 in “Science” This study found that aged tritiated thymidine breaks down and incorporates into cytoplasmic macromolecules, not DNA, suggesting caution in its use.
2 citations
,
November 2022 in “Biosensors” This study introduced a new spectrofluorometric method using a synthesized organic fluorophore to effectively analyze darolutamide and thalidomide in pharmaceutical preparations and biofluids.
26 citations
,
October 2011 in “International Journal of Biological Macromolecules” This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.
February 2020 in “Central Plains Medical Journal” In this study, combining thalidomide with CHOP treatment showed a significantly higher effective rate in treating peripheral T-cell lymphoma compared to CHOP alone, while both regimens were associated with similar levels of adverse reactions.
75 citations
,
June 2007 in “Journal of Biological Chemistry” This study found that the combination of MT-DADMe-ImmA and MTA selectively induced apoptosis in head and neck squamous cell carcinoma cell lines FaDu and Cal27, but not in normal fibroblasts or MTAP-deficient breast cancer cells.
51 citations
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March 2006 in “Bioorganic & Medicinal Chemistry” This study screened synthesized pyridinecarboxamides for antitumor properties and found that many, particularly 5c and 7a, showed moderate in vitro activity against various human tumor cell lines.
21 citations
,
January 2021 in “Frontiers in Pharmacology” This review examines the role of thiopurines in managing inflammatory bowel diseases like ulcerative colitis and Crohn's disease, and reports no new clinical results, emphasizing the need for more studies on thiopurine withdrawal scenarios.
18 citations
,
April 2001 in “Bioorganic & Medicinal Chemistry Letters” This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.
8 citations
,
January 2013 in “Medicinal chemistry” This study reported that among 10 tested 2-(4-chlorophenyl)-5-aryl-1,3,4-oxadiazole compounds, compound 4c showed the highest activity against cancer cell lines, with a 95.37% average growth rate.
86 citations
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November 2015 in “Journal of Gastroenterology” This study reported that the NUDT15 R139C genetic variant was significantly associated with thiopurine-induced leukocytopenia in Japanese inflammatory bowel disease patients, independent of 6-thioguanine nucleotide levels.
87 citations
,
January 1996 in “Journal of cellular biochemistry” This article discusses ongoing and planned clinical chemoprevention trials for various agents and combinations but reports no new results; it highlights promising new agents and the evolving focus on molecular pathways.
November 2012 in “Journal of Clinical Pathology” 16 citations
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September 1999 in “Journal of Investigative Dermatology Symposium Proceedings” This article reviews the history and dermatologic side effects of alkylating agents used in chemotherapy, noting that some agents like chlorambucil can cause recurrent symptoms upon rechallenge, whereas others are tolerated.
April 2023 in “Journal of Investigative Dermatology” This study found that ALRN-6924 effectively protected human hair follicles from cyclophosphamide-induced damage in an ex vivo setting, suggesting it may reduce both acute and permanent chemotherapy-induced alopecia.
This article lists the clinically important interactions and skin reactions of several drugs and substances, including THA, FK506, tamoxifen, tamsulosin, tartrazine, tea tree oil, temazepam, and temozolomide, but provides no new clinical results.