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AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Mobile phone radiation may cause DNA damage in human ear hair follicle cells.

The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.

The AIRE gene variant rs2075876 is linked to a higher risk of alopecia areata in males.

New steroids were effective in blocking male hormone receptors in hamster prostates.

All medications can cause skin rashes, often without a clear cause, and better tests are needed to identify these drug-related skin issues.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

PRX01, PRX44, and PRX73 are essential for root hair growth in Arabidopsis thaliana.

Hemp is a promising ingredient for skin products due to its healing and soothing properties.

Cannabinoids might help treat skin problems but more research is needed to be sure.

The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Scientists found new, better-working inhibitors for a hormone-related enzyme.

Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.

New method makes important drug ingredients more easily without needing extra purification steps.

Monocyclic aromatic compounds are important for developing various drugs and treatments.

16-MHA can restore the barrier and moisture of damaged hair, making it similar to undamaged hair.

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.