This study suggests that hair follicle dermal stem/progenitor cells play a key role in both hair regeneration and skin wound healing, with potential implications for preventing hair follicle miniaturization linked to aging or alopecia.
41 citations
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April 2009 in “Journal of comparative neurology” In this study, researchers observed that P2X3-immunoreactive fibers extensively innervate the epidermis of rats, suggesting a primary role in detecting noxious stimuli in cutaneous tissue.
39 citations
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November 2016 in “Pharmaceutics” This study found that the contribution of the hair follicle pathway to skin permeation of chemicals can be predicted using lipophilicity, with hydrophilic chemicals showing greater permeation reduction from hair follicle plugging than lipophilic ones.
173 citations
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August 2015 in “Developmental cell” This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.
56 citations
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March 2015 in “Journal of Investigative Dermatology” Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
55 citations
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September 2017 in “Journal of Cosmetic Dermatology” This review discusses the diverse applications of platelet-rich plasma in aesthetic dermatology and assesses the existing literature on its effectiveness, reporting no new clinical results.
44 citations
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September 2019 in “The EMBO Journal” This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.
38 citations
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September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
20 citations
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August 2007 in “Molecular therapy” This study found that inducing hair follicles into the anagen-onset stage in mice enhances the immune response to a topically applied DNA vaccine against anthrax.
19 citations
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June 2020 in “Animals” This study found that maternal sub-maintenance nutrition reduced the density and branching ratio of secondary wool follicles in Merino sheep fetuses and identified genes potentially involved in these processes.
16 citations
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December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
14 citations
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April 2019 in “Saudi pharmaceutical journal” This study reported that microparticle-loaded emulsions containing caffeic acid achieved more homogeneous distribution and prolonged release in hair follicles, suggesting potential for effective folliculitis treatment.
11 citations
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December 2011 in “International journal of pharmaceutics” In this study, brief ultrasound exposure reduced the follicular contribution to hydrocortisone absorption while significantly increasing total skin permeability, likely due to removal of the upper stratum corneum.
9 citations
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July 2018 in “European journal of dermatology/EJD. European journal of dermatology” This study provides evidence that long-term deregulation of the circadian rhythm in humans affects the regenerative properties of skin and hair precursor cells by altering clock pathway protein expression.
6 citations
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December 2022 in “Cell reports” This study found that feeding mice a high-fat diet with fish oil leads to hair loss through a mechanism involving omega-3 fatty acids and TNF-α signaling, with epidermal fatty acid binding protein playing a key role.
6 citations
,
January 2018 in “Multimedia Tools and Applications” This study proposes a method for automatically removing hairs from skin lesion images by using edge-tangent flow for hair detection and texture synthesis for restoring occluded regions with minimal artifacts.
1 citations
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July 2023 in “Cytotherapy” In this study, MSC-derived magnetic nanovesicles combined with a magnetic field increased skin retention and accelerated hair follicle growth in a mouse model of hair regeneration.
April 2026 in “International Journal of Molecular Sciences” This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a skincare product effectively prevented and reduced pollen allergen accumulation in hair follicle models by forming a protective film and exhibiting strong cleansing properties, suggesting its potential to protect skin from environmental elements that can lead to irritation and allergic reactions.
103 citations
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November 2014 in “Journal of Cell Biology” This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
This study suggests that bio-nanovesicles, such as exosomes and microvesicles, may enhance skin and hair follicle regeneration by modulating key signaling pathways, potentially overcoming the limitations of conventional treatments for alopecia and chronic skin diseases.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the potential of rice water, traditionally used in Asian skincare and haircare, due to its nutritional and bioactive components that may improve skin hydration and hair health, supported by its antioxidant, anti-inflammatory, antimicrobial, and anti-aging properties.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this review, researchers examine rice water, a traditional Asian skincare and haircare remedy, highlighting its nutritional and bioactive components which may enhance skin and hair health through hydration, protection, and shine improvement, and detailing its potential roles in various cosmetic formulations.
This review discusses forensic DNA phenotyping and its potential applications, particularly for human identification in Latin American populations, but notes challenges due to genetic diversity and reports no new results.
August 2025 in “http://isrctn.com/” The supplement may improve hair growth and skin health with some mild risks.
In this clinical trial, the researchers observed that a biotin and silica supplement reduced hair fall, increased hair growth rate, and improved skin elasticity, hydration, and nail quality over 90 days without adverse effects.
July 2025 in “Cosmoderma” In this study, a 90-day course of a plant-based supplement significantly improved hair density, skin hydration, and nail growth among participants with dermatological concerns, while also reducing hair fall and pigmentation, without adverse effects.
July 2025 in “Current Issues in Molecular Biology” This study evaluated the safety and efficacy of Bio-Pulsed avian mesenchymal stem cell-derived small extracellular vesicles when applied topically, finding significant improvements in hair growth, skin rejuvenation, and regenerative microRNA presence among 60 human participants without adverse events.
May 2025 in “Journal of Extracellular Vesicles” This study found that extracellular vesicles from erythrocytes may promote hair regeneration in patients with androgenic alopecia by transferring components that upregulate Wnt/β-catenin signaling and are involved in the formation of the skin's outer barrier.
February 2025 in “The Open Dermatology Journal” In this study conducted at Afzalipour Hospital in Iran, researchers found a significant prevalence of alopecia, particularly resembling telogen effluvium, among COVID-19-recovered patients, with hair loss being more common in females and correlating with arterial oxygen saturation levels.