30 citations
,
April 2013 in “Journal of Investigative Dermatology” This study found that ionizing radiation primarily affects keratinocyte stem cells in the hair follicle, suggesting they play a central role in radiation-induced hair graying, rather than melanocyte stem cells.
61 citations
,
July 2011 in “PLOS ONE” This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.
October 2025 in “Current Pharmaceutical Research” This study evaluated a new herbal shampoo made from traditional plants and found it to have effective cleansing properties, moderate foam stability, and environmental safety, suggesting it as a favorable natural alternative to synthetic shampoos.
2 citations
,
November 2019 in “FEBS open bio” This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
233 citations
,
February 2018 in “Polymers” This review examines the roles and benefits of chitosan in cosmetics and oral hygiene, highlighting its potential in the cosmeceutical market, but it reports no new results.
22 citations
,
October 2012 in “Cell Transplantation” This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.
9 citations
,
December 2014 in “Daehan miyong hakoeji” Peppermint oil promotes hair growth and fights bacteria better than minoxidil.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study demonstrated that a natural polyherbal shampoo powder, made from ingredients like shikakai and neem, showed promising anti-dandruff and antifungal properties, with good foaming capacity and ease of washability, suggesting it could be a safe and eco-friendly alternative to synthetic shampoos.
2 citations
,
February 2024 in “Nature cell biology” In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.
36 citations
,
January 2019 in “Nature communications” This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the growing popularity and benefits of herbal shampoos, which use plant-based extracts to provide a gentle, effective, and environmentally friendly alternative to conventional chemical shampoos, promoting hair health and eco-sustainability.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the benefits and preparation of herbal shampoos using plant-based extracts, which are found to clean gently, strengthen hair, promote growth, reduce dandruff, and improve hair texture while being environmentally friendly due to their non-toxic and biodegradable properties.
June 2022 in “International Journal of Advanced Research in Science, Communication and Technology” In this study, a herbal shampoo containing fermented rice water and various traditional herbs was found to exhibit good foaming ability, cleansing properties, and was effective in treating hair loss.
April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies key transcriptomic features and a necessary dermal niche for eccrine gland development, advancing potential regenerative approaches for these vital skin appendages.
July 2020 in “International journal for research in applied science and engineering technology” This study reports that a newly formulated herbal shampoo using natural ingredients like fenugreek and shikakai was successfully developed to eliminate harmful synthetic components in anti-dandruff shampoos.
This study found that selective deletion of PIKFyve kinase using a PF4 promoter in mice led to defective platelet lysosome biogenesis and a prothrombotic effect, with unexpected macrophage infiltration in multiple organs.
30 citations
,
August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.
72 citations
,
December 1996 in “Journal of Investigative Dermatology” This study observed that human hair follicles were able to regenerate fiber-forming structures after the bulb was amputated and transplanted onto athymic mice, suggesting a general regenerative capacity.
1 citations
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May 2024 in “Communications Biology” This study found that Dab2 conditional knockout mice experienced delayed hair follicle cycles and reduced hair follicle stem cell activity, suggesting Dab2's crucial role in regulating stem cell activation and anti-aging process in hair follicles.
This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.
October 2024 in “Current Trends in Biotechnology and Pharmacy” In this study, researchers developed a halal shampoo containing Centella asiatica and Phyllanthus emblica extracts, finding that a formula with specific concentrations exhibited high antioxidant activity and ideal physicochemical properties for hair cleansing and potential hair growth promotion.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed and tested a natural polyherbal shampoo powder, finding it to have strong anti-dandruff and antifungal properties, good foaming capacity, acceptable pH, and no skin irritation, suggesting it as a safe and eco-friendly alternative to synthetic shampoos.
September 2022 in “Institutional Repositories DataBase (IRDB)” Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.
2 citations
,
November 2023 in “Journal of Natural Products” In this study, researchers accomplished the total synthesis of calanthoside, noted for its strong proliferative effects on human hair follicle dermal papilla cells, using a seven-step process from anthranilic acid with a 43% overall yield.
45 citations
,
November 2022 in “Acta Biomaterialia” This study developed a biomimetic 3-D co-culture system that enhances the hair-inductive properties of human dermal papilla cell aggregates, potentially improving hair follicle tissue engineering.
November 2024 in “Journal of Scientific Agriculture” This paper reviews the benefits of using silk proteins as natural ingredients in cosmetics, highlighting their potential for improving skin and hair health due to properties like antimicrobial activity, UV resistance, and enhanced moisture absorption.
66 citations
,
December 2013 in “Nature Cell Biology” This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.
December 2014 in “대한미용학회지” In this study, 3% peppermint oil promoted hair regrowth faster than 3% minoxidil in mice and showed strong antibacterial activity against P. ovale.
57 citations
,
November 1998 in “Wound Repair and Regeneration” This research observed that dermal papilla cells have the potential to regenerate hair bulbs under preferred environmental conditions when associated with dermal sheath cells or exposed to specific growth factors.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, the researchers developed and evaluated a polyherbal powder shampoo using Ayurvedic plants, concluding that formulation F3 effectively provides eco-friendly and safe hair care with antimicrobial properties, making it a promising alternative to synthetic shampoos.