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Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.

Alopecia is not a significant predictor of thyroid disease when age and sex are considered.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

Minoxidil lotion may harm male reproductive health.

A woman with childhood growth hormone deficiency had multiple hormone deficiencies and developed serious lung and kidney problems later in life.

Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.

Some medications might contribute to male infertility, with finasteride showing a high number of reports.

Certain vitamins in wrong amounts, alcohol abuse, metals, and other toxins can cause serious brain and nerve damage.

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

Hair microscopy is useful for diagnosing hair disorders, but clear definitions are needed for accurate genetic analysis.

Anorexia nervosa may cause a hair defect called pili torti due to malnutrition and high vitamin A levels.

Hair's structure and properties change with pH; acidic pH maintains strength and less swelling, while alkaline pH increases water content and swelling.

Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

Certain diseases like AIDS and lupus can make African hair become silky.

The document concludes that unruly hair can be congenital or acquired, often lacks specific treatments, and can be managed with oils and short hairstyles.

Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.

Alopecia areata involves immune response and gene changes affecting hair loss.

Dlx3 is essential for hair growth and regeneration.

Some children are born with unusually short, fine hair because their hair growth phase is short, but this often gets better by itself during puberty.

TGM3 is important for skin and hair structure and may help diagnose cancer.

Monilethrix causes fragile, patchy hair loss.

Different types of hair loss require specific treatments, and new treatments are being developed.

Eating the right nutrients can improve hair health, but taking extra supplements usually doesn't help unless you have a deficiency.

Robotic hair transplantation surgery is generally effective with high satisfaction rates and minimal complications.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Some congenital hair disorders improve in childhood or with treatments like minoxidil and retinoids, while others like Netherton syndrome and trichothiodystrophy have a poor prognosis.

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

Taking vitamins, minerals, and amino acids can improve hair strength and quality in people with Monilethrix.