42 citations,
January 2021 in “Journal of Clinical Medicine” Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.
October 2024 in “International Journal of Pharmaceutical Sciences Review and Research” A 5% minoxidil spray could effectively treat male baldness with fewer side effects and better patient comfort.
33 citations,
April 1990 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, with better results in women.
19 citations,
March 1990 in “Journal of Cardiovascular Pharmacology” Minoxidil affects rat fluid dynamics, altering pressure and circulation, improving blood flow and hair growth.
1 citations,
December 2022 in “Pharmaceuticals” Noni fruit extract, specifically the FEA-3 sub-fraction, can increase hair growth and reduce baldness in male rabbits, potentially acting like common hair loss treatments.
November 2022 in “Cureus” New biomaterial treatments for baldness show promise, with options depending on patient needs.
January 2022 in “Advanced Pharmaceutical Bulletin” Clove oil and grape seed extract increase finasteride skin absorption, while urea decreases it.
April 2024 in “Indian journal of ophthalmology. Case reports” Using minoxidil for hair loss might rarely cause a vision problem where fluid builds up under the retina.
21 citations,
December 2007 in “Journal of Investigative Dermatology” Hair follicles evolved from oil glands, with hair aiding secretion transport.
July 2024 in “Pharmaceutical Development and Technology” Microsponges with rosemary oil significantly improve hair growth compared to regular rosemary oil and minoxidil.
63 citations,
April 2005 in “Mechanisms of development” Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.
30 citations,
October 2015 in “Journal of Ethnopharmacology” Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.
The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
76 citations,
June 2015 in “Journal of biomedical science” Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
3 citations,
November 2018 in “Journal of cellular physiology” Serenoa repens and N-acetyl glucosamine/milk proteins complex may help with hair growth and prevent hair loss.
39 citations,
August 2017 in “Colloids and Surfaces B: Biointerfaces” 50-nm nanoparticles are better at penetrating skin and targeting hair follicles for drug delivery than 100-nm ones.
48 citations,
May 2018 in “Expert Opinion on Therapeutic Targets” Gut health may influence Alopecia Areata, suggesting new treatments.
March 2021 in “CRC Press eBooks” Microneedling helps improve skin and hair by creating tiny, controlled skin injuries.
118 citations,
May 2015 in “European journal of pharmaceutics and biopharmaceutics” The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.
13 citations,
November 2022 in “Biomaterials Science” The microneedle patch effectively promotes hair regrowth by delivering miR-218.
February 2024 in “Pharmaceutical research” Hair follicles affect how well small molecules can pass through the skin, and this varies depending on the molecule's features.
2 citations,
January 2018 in “Elsevier eBooks” Probiotics and dietary changes can help treat acne.
April 2017 in “Journal of Investigative Dermatology” Applying pseudoceramide improved skin and hair health.
1 citations,
January 2012 in “Human health handbooks” Linoleic acid is important for healthy skin, and while most people get enough from their diet, not having enough can cause skin and hair problems.
January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)” Carthamus tinctorius floret extract is a safe hair growth promoter with good skin absorption.
April 2023 in “Journal of Drug Delivery Science and Technology” The new minoxidil gel improves hair growth and reduces skin irritation.
December 2024 in “Chinese Chemical Letters” A new topical finasteride gel using nanoparticles shows promise for safe and effective hair regrowth.
39 citations,
November 2016 in “Pharmaceutics” The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.
21 citations,
December 2015 in “European journal of cell biology” Tight junctions create a barrier in pig hair follicles that controls what can enter the skin.
3 citations,
January 2016 in “BioMed research international” Calcium microcapsules are better for long-term use in artificial dermal papilla, while barium microcapsules are good for short-term.