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Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

JAK inhibitors may become the first approved treatment for alopecia areata if they are proven safe and effective.

Combining microneedling with platelet-rich plasma enhances skin repair and collagen production but may not offer significant extra benefits.

Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The hedgehog signalling pathway is key in skin development and basal cell carcinoma, offering insights for prevention and treatment.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Recombinant human epidermal growth factor is versatile, effective, and safe for long-term skin and mucosal treatments.

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

Polyamines help repair DNA breaks and may influence cancer development.

Skin organoids from stem cells can help study and treat skin issues but face some challenges.

SCD1 is crucial for skin health and overall energy balance.

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Certain spices may help prevent and treat skin cancer, but more human trials are needed.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

Black cumin and its nanoformulations show promise in treating neurodegenerative diseases.

CGF therapy may effectively treat psoriasis by reducing inflammation.

Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.

A special gene region controls the re-emergence of a primitive wool type in Merino sheep, improving their wool yield and adaptability.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

The conclusion is that recognizing the difference between gender identity and biological sex is crucial in dermatology to improve patient care and research accuracy.

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

PRP treatment helps hair growth and rebalances scalp bacteria in androgenetic alopecia patients.

Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.

Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.

Older hair follicle stem cells have a reduced ability to renew themselves, leading to more hair loss.

Activating Nrf2 helps wounds heal faster by increasing hair follicle stem cells.