6 citations
,
October 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” This study found that rice bran ash extract enhanced melanin biosynthesis-related protein expression in a 3D hair follicle-like tissue model and hair follicle organ culture, suggesting potential for future research in melanogenesis.
36 citations
,
October 1996 in “Dermatologic Clinics” In this study, a methanol extract of Eclipta alba was found to have dose-dependent hair growth-promoting activity in C57BL6 mice.
34 citations
,
December 1991 in “Annals of the New York Academy of Sciences” The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.
26 citations
,
August 2022 in “Stem Cells Translational Medicine” This review highlights the limitations of mouse models in human hair loss research and emphasizes the potential of using human cell bioengineered models and artificial intelligence for future advancements, but reports no new clinical results.
5 citations
,
November 2017 in “Elsevier eBooks” This review highlights recent advances in hair follicle research, noting that new 3D culture techniques have enabled formation of HF-like structures in vitro, offering potential benefits for alopecia and burn patients, but it reports no new clinical results.
October 2023 in “Recent Trends in Pharmaceutical Sciences and Research” This review examines the anatomy and physiology of hair, focusing on the hair growth cycle and various types of alopecia, using animal models such as mice and rats to study the condition's pathophysiology and aid in developing new treatments.
208 citations
,
January 2013 in “Lab on a Chip” The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.
48 citations
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June 2013 in “Journal of Dermatological Science” This study found that valproic acid promoted human hair growth by increasing β-catenin levels, suggesting it may be a potential therapeutic option for alopecia.
27 citations
,
June 2015 in “Journal of photochemistry and photobiology. B, Biology” This study reported that sunscreen with SPF50+ provides a high level of DNA protection against UV-induced damage in a reconstituted human epidermis model, comparable to that in skin explants.
16 citations
,
November 2020 in “In Vitro Cellular & Developmental Biology - Animal” This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.
15 citations
,
April 2014 in “Experimental Dermatology” This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.
11 citations
,
March 2001 in “Clinics in dermatology” This study found that using a novel dissolving microneedle with valproic acid effectively enhances hair follicle regrowth through improved delivery and activation of the Wnt/β-catenin pathway compared to topical application.
4 citations
,
January 2015 in “Experimental Dermatology” This study developed a humanized scalp model in mice which demonstrated that transplanted cultured human hair follicle dermal cells contributed to the restoration of damaged hair follicles.
July 2026 in “Frontiers in Bioengineering and Biotechnology” This study reports that Echinacea-loaded silk fibroin/chitosan dressings may effectively promote scarless skin regeneration and accelerate wound healing compared to conventional treatments.
July 2024 in “ACS Biomaterials Science & Engineering” In this study, researchers used a 3D in vitro organ culture system to show that rifampicin-loaded lipid nanocapsules can penetrate hair follicles more effectively than free rifampicin, highlighting the potential advantage of nanocarrier-based antibiotic treatments for follicular infections.
This study developed a mathematical model using hair biomarkers (levels of Mg, K, Fe, Al, Cr) to noninvasively predict iron content in Hereford cattle muscle tissue, potentially improving livestock management and meat quality.
September 2018 in “Cosmetics” This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study concluded that a new model of reconstructed human epidermis using keratinocytes from plucked hair follicles offers a less-invasive alternative to conventional skin-derived models for skin research.
16 citations
,
April 2021 in “International Journal of Molecular Sciences” This study found that micro-current electrical stimulation may promote hair growth in human hair follicle-derived papilla cells and a mice model by enhancing cell proliferation, migration, and activating key growth pathways.
65 citations
,
January 2021 in “Burns & Trauma” This study developed an in vitro model revealing that hair follicle spheroids enhanced both sweat gland and hair follicle differentiation within bioprinted scaffolds, while microenvironmental cues supported persistent regeneration.
11 citations
,
January 2013 in “Veterinary dermatology” This study found that a bulge stem cell-enriched population from canine hair follicles successfully formed interfollicular epidermis in vitro within two weeks, suggesting potential for regenerative canine skin therapies.
April 2026 in “Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences” In this study using a mouse model, researchers observed that topical nifedipine cream at 0.3% concentration promoted hair growth more effectively than 2% minoxidil solution, suggesting that nifedipine may have potential as a hair growth treatment.
66 citations
,
June 2010 in “Experimental Dermatology” This paper argues that the cycling hair follicle serves as a valuable model for systems biology research, highlighting its potential for translational medicine.
5 citations
,
April 2024 in “Biology” This review explores the current understanding of hair follicle development and regeneration, emphasizing the molecular pathways involved and the potential for bioengineering hair follicles in vitro to advance hair regeneration strategies.
3 citations
,
March 2023 in “Scientific Reports” This study found that organoid cultures of human epithelial and mesenchymal cells can produce hair peg-like structures, and their growth is enhanced by minoxidil, suggesting potential for hair drug screening.
76 citations
,
August 2018 in “International Journal of Cosmetic Science” This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.
9 citations
,
August 2013 in “Journal of Tissue Engineering and Regenerative Medicine” In this study, neonatal murine skin-derived cells transplanted using a mini-chamber method successfully produced robust and normal hair, contrasting with human scalp follicles which did not achieve follicle reconstruction.
8 citations
,
January 2015 in “Clinical and Experimental Dermatology” This study found that an improved flap model in nude mice significantly reduces the time needed for hair induction compared to the traditional method, likely due to enhanced blood supply at the transplantation sites.
133 citations
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July 1994 in “Journal of Dermatological Science” In this study, the researchers developed an in vitro model that maintains human hair follicles to grow at in vivo rates and observed that factors like EGF and IGF-I influence hair follicle growth and catagen entry.
124 citations
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August 1994 in “Journal of Investigative Dermatology” This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.