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    Glossary Hair Germ Cells

    specialized cells initiating new hair follicle growth

    Hair germ cells are specialized cells found in the hair follicle that play a crucial role in the initiation of new hair growth. They are derived from stem cells and are responsible for the early stages of hair follicle development and regeneration, making them essential for maintaining healthy hair cycles.

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    1. 1017 The prostaglandin F2α analog bimatoprost activates secondary hair germ cells to promote hair growth through two distinct signaling pathways Journal of Investigative Dermatology · 2026
    2. Impact of adipose-derived stem cells on engineering hair follicle germ-like tissue grafts for hair regenerative medicine Journal of Bioscience and Bioengineering · 2021 · 11 citations
    3. Ber‐EP4 antigen is a marker for a cell population related to the secondary hair germ Experimental Dermatology · 2004 · 21 citations
    4. Male androgenetic alopecia is due to hair follicle stem cell inactivation Expert Review of Dermatology · 2011 · 3 citations
    5. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Development · 2013 · 60 citations
    6. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    7. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss Nature Cell Biology · 2017 · 56 citations
    8. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017 · 42 citations
    9. Baldness, acne and testicular germ cell tumours International Journal of Andrology · 2010 · 31 citations
    10. The Hair Follicle Bulge: A Niche for Adult Stem Cells Microscopy and Microanalysis · 2011 · 19 citations
    11. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration Journal of Cell Science · 2013 · 3 citations
    12. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    13. Faculty Opinions recommendation of Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    14. Cell proliferation during fibre growth initiation in ferret hair follicles Proceedings of the New Zealand Society of Animal Production · 1992
    15. Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ Methods in molecular biology · 2016 · 6 citations
    16. Skin-derived stem cells as a source of primordial germ cell- and oocyte-like cells Cell death and disease · 2016 · 24 citations
    17. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    18. Induced pluripotent stem cell line MUSIi006-A derived from hair follicle keratinocytes as a non-invasive somatic cell source Stem cell research · 2018 · 7 citations
    19. Peer Review #1 of "Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning (v0.1)" 2016
    20. Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis BMC Cancer · 2018 · 3 citations
    21. Changing Patterns of Localization of Putative Stem Cells in Developing Human Hair Follicles Journal of Investigative Dermatology · 2000 · 87 citations
    22. 319 Mechanisms of cell death regulation in hair regeneration 2021
    23. MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells Proceedings of the National Academy of Sciences · 2023 · 11 citations
    24. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    25. MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells bioRxiv (Cold Spring Harbor Laboratory) · 2022
    26. A novel cell-free regenerative therapy for hair loss: human fetal cartilage progenitor cell secretome Biomaterials · 2025
    27. Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germ-Line Stem Cells Stem Cells and Development · 2008 · 14 citations
    28. Single-Cell Transcriptomic Identification of a Proliferative Intermediate State During Early Anagen Hair Follicle Regeneration Genes · 2026
    29. Basonuclin as a cell marker in the formation and cycling of the murine hair follicle Differentiation · 1998 · 27 citations
    30. Two’s Company, Three’s a Hair Cycle? hfDSCs Join the Hair Germ–Dermal Papilla Regulatory Interface Journal of Investigative Dermatology · 2025