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Human skin can make serotonin and melatonin.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

New nanocomposites with copper show promise for healing burn wounds and regenerating skin.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

The document concludes that the effectiveness of platelet rich plasma in aesthetic surgery is unclear due to inconsistent reporting and lack of objective measures in studies.

Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Stem cell niches are adaptable and key for tissue maintenance and repair.

Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.

Plant-based ingredients are effective and safe for modern skincare products.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.