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GlossaryHair Follicle Mesenchymal Stem Cells

cells in hair follicles that can become various tissue types

Hair Follicle Mesenchymal Stem Cells (HF-MSCs) are a type of stem cell found within the hair follicle that have the ability to differentiate into various cell types, including those that form skin, hair, and connective tissues. These cells play a crucial role in hair growth, wound healing, and tissue regeneration, making them a significant focus in regenerative medicine and treatments for conditions like alopecia.

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Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations, April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

research Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes

17 citations, May 2014 in “Cell transplantation”

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

research The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

8 citations, February 2021 in “Journal of Clinical Medicine”

Hair follicle stem cells are promising for blood vessel formation and tissue repair.

research Transplanted Hair Follicle Mesenchymal Stem Cells Alleviated Small Intestinal Ischemia–Reperfusion Injury via Intrinsic and Paracrine Mechanisms in a Rat Model

6 citations, October 2022 in “Frontiers in Cell and Developmental Biology”

Transplanted hair follicle stem cells can heal damaged rat intestines.

Ficoll Density Gradient Sedimentation Isolation of Pelage Hair Follicle Mesenchymal Stem Cells from Adult Mouse Back Skin: A Novel Method for Hair Follicle Mesenchymal Stem Cells Isolation

research Ficoll Density Gradient Sedimentation Isolation of Pelage Hair Follicle Mesenchymal Stem Cells from Adult Mouse Back Skin: A Novel Method for Hair Follicle Mesenchymal Stem Cells Isolation

March 2022 in “Research Square (Research Square)”

The new method isolates more hair follicle stem cells from mice quickly and these cells help promote hair growth.

research Hair Regrowth with Micrografts Enriched with Human Follicle Mesenchymal Stem Cells and Platelet-Rich Plasma

January 2022 in “Springer eBooks”

Using micrografts with stem cells and platelet-rich plasma can safely and effectively help regrow hair.

Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

research Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

73 citations, August 2011 in “Stem Cell Research”

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.

research Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

15 citations, January 2015 in “Stem cells international”

Human hair follicle stem cells can be turned into red blood cells.

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

11 citations, October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

research Ficoll Density Gradient Sedimentation Isolation of Pelage Hair Follicle Mesenchymal Stem Cells From Adult Mouse Back Skin: A Novel Method for Hair Follicle Mesenchymal Stem Cells Isolation

2 citations, July 2022 in “Stem cell research & therapy”

A new method quickly and efficiently isolates hair follicle stem cells from adult mice, promoting hair growth.

research Human Hair Follicle-Derived Mesenchymal Stem Cells Promote Tendon Repair in a Rabbit Achilles Tendinopathy Model

April 2023 in “Chinese Medical Journal”

Human hair follicle stem cells help repair tendon injuries.

Stimulation by Exosomes from Hypoxia-Preconditioned Hair Follicle Mesenchymal Stem Cells Facilitates Mitophagy by Inhibiting the PI3K/AKT/mTOR Signaling Pathway to Alleviate Ulcerative Colitis

research Stimulation by Exosomes from Hypoxia-Preconditioned Hair Follicle Mesenchymal Stem Cells Facilitates Mitophagy by Inhibiting the PI3K/AKT/mTOR Signaling Pathway to Alleviate Ulcerative Colitis

January 2024 in “Theranostics”

Exosomes from special stem cells help treat ulcerative colitis by reducing inflammation and stress.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

26 citations, August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations, February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

research PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

9 citations, November 2021 in “Frontiers in Cell and Developmental Biology”

PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.

research Comparative Characterization and Osteogenic/Adipogenic Differentiation of Mesenchymal Stem Cells Derived from Male Rat Hair Follicles and Bone Marrow

6 citations, August 2020 in “Cell regeneration”

Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

83 citations, January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Mesenchymal Stromal Cell-Derived Magnetic Nanovesicles for Enhanced Skin Retention and Hair Follicle Growth

1 citations, July 2023 in “Cytotherapy”

Magnetic nanovesicles from stem cells can improve hair growth by staying in the skin longer.

research Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine

65 citations, November 2012 in “Tissue Engineering Part B-reviews”

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations, January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

research From Hair to Liver: Emerging Application of Hair Follicle Mesenchymal Stem Cell Transplantation Reverses Liver Cirrhosis by Blocking the TGF-β/Smad Signaling Pathway to Inhibit Pathological HSC Activation

4 citations, February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study

research Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study

October 2024 in “Aesthetic Plastic Surgery”

Micrografts are a safe and effective treatment for hair loss in both men and women.

research Research Progress on Targeted Regulation of Hair Follicle Stem Cell Function in the Treatment of Androgenetic Alopecia

January 2024 in “Pharmacy information”

New treatments using stem cells and other methods show promise for promoting hair growth in androgenetic alopecia.

research Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

4 citations, June 2022 in “BioMed Research International”

Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.

research Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

3 citations, January 2021 in “Oxidative Medicine and Cellular Longevity”

Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.

research Impact of Stem Cell-Based Therapy and Platelet-Rich Plasma in Hair Loss and Telogen Effluvium Related to COVID-19

July 2023 in “Regenerative Therapy”

Stem cell and platelet-rich plasma therapies show promise for COVID-19 related hair loss, but more research is needed.

research Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

5 citations, April 2022 in “Frontiers in Medicine”

Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.

research From Hair to Colon: Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner

1 citations, September 2022 in “Oxidative Medicine and Cellular Longevity”

Hair follicle stem cells can help treat ulcerative colitis in mice by releasing beneficial exosomes.

research The Dermal Papilla and Hair Follicle Regeneration: Engineering Strategies to Improve Dermal Papilla Inductivity

January 2022 in “Stem cell biology and regenerative medicine”

Improving dermal papilla cells can help regenerate hair follicles.