38 citations
,
June 2019 in “International Journal of Molecular Sciences” This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.
26 citations
,
January 2013 in “BioMed Research International” This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
November 2025 in “Nature Communications” This study used a 3D live imaging system to map cell dynamics in human hair follicles, revealing patterns of cell movement and division that help explain hair fiber extrusion during hair growth.
11 citations
,
June 2017 in “Mathematical Medicine and Biology A Journal of the IMA” This mathematical model of alopecia areata illustrates how inflammatory autoimmune responses interrupt the anagen phase of hair growth, and may help evaluate treatments and identify new therapeutic targets.
135 citations
,
December 2013 in “Seminars in Cell & Developmental Biology” This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.
3 citations
,
July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model” This study found that mouse hair follicle stem cells in a quiescent state exhibit greater chromatin dynamics and de-differentiation potential, suggesting higher cell fate plasticity compared to their proliferative or differentiated counterparts.
This study provides a detailed analysis of cell subpopulations in a mouse model of wound-induced hair follicle regeneration, revealing specific cellular dynamics and heterogeneity that may influence hair follicle neogenesis.
December 2025 in “Brazilian Journal of Hair Health” This integrative review developed a Spiral Model to better represent human hair follicle dynamics and aging, which may assist in distinguishing natural aging from pathological changes and improving trichological interventions.
158 citations
,
May 2003 in “Journal of Investigative Dermatology” This study observed that hair follicle mesenchyme in mice exhibits significant plasticity during the hair cycle, with cell migration and changes in papilla size impacting hair production.
67 citations
,
February 1994 in “Developmental dynamics” This study analyzed the distribution of adhesion molecules and extracellular matrix components in human fetal skin, suggesting their roles in hair follicle development.
60 citations
,
July 2011 in “Stem Cells and Development” This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.
54 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This speculative review discusses hair cycle-dependent fibroblast dynamics and possible impacts on human hair growth, synthesizing current literature without presenting new clinical findings.
54 citations
,
June 1985 in “American Journal of Dermatopathology” This abstract does not provide specific findings or results.
44 citations
,
September 2019 in “The EMBO Journal” This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.
38 citations
,
April 2016 in “Experimental Dermatology” This review discusses immunohistological and immunofluorescent methods for studying the human hair follicle cell cycle, reporting no new results, and suggests its potential for advancing cell cycle research.
12 citations
,
January 2021 in “Journal of Investigative Dermatology” This review discusses the role of telomere length dynamics in hair follicle biology and reports no new clinical findings, emphasizing the need for further research in humans.
2 citations
,
December 2025 in “Nature Communications” This study found that the repressive histone mark H2AK119ub links inhibitory FGF signals with the quiescent state in hair follicle stem cells, revealing a signaling-epigenetic axis crucial for maintaining stem cell quiescence and tissue homeostasis.
This review highlights Malassezia's dual role as both protective and pathogenic within the hair follicle ecosystem, noting its involvement in skin disorders and potential cancer progression, and calls for further studies to develop targeted treatments for related conditions.
October 2010 in “eCommons (Cornell University)” This study found that mouse hair follicle stem cells use symmetric cell division for maintenance and fate determination, and identified Gata6 as a crucial factor for their differentiation.
25 citations
,
July 2008 in “British Journal of Dermatology” This study observed dynamic changes in CD10 and CD34 expression in fetal and adult human hair follicles during embryogenesis and hair cycling.
22 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.
December 2016 in “Clinics in surgery” This article reviews the epidemiology, pathophysiology, and management of androgenetic alopecia, highlighting recent insights into stem cell niches in hair follicles without presenting new experimental findings.
4 citations
,
January 2011 in “Cell stem cell” This study reveals that stem cell descendants in mouse hair follicles can return to their niche to retain stemness and function as primary stem cells for future hair cycles.
3 citations
,
February 2014 in “Asian Pacific journal of tropical medicine” This study observed that Wnt5a mRNA expression in mice correlates with the hair cycle and inhibits hair follicle growth by antagonizing the Wnts pathway.
August 2026 in “Animal Genetics” In this study, researchers analyzed hair follicle development in Yongqing Rex rabbits, finding dynamic changes in fur thickness, coat density, and hair structure across 1 to 6 months, along with fluctuations in follicle density and gene expression linked to hair growth and quality.
June 2026 in “Frontiers in Bioengineering and Biotechnology” This review outlines the transition from simple hair follicle organoids to immune-competent microphysiological systems, addressing limitations in replicating native hair follicle immune features and discussing their applications in disease modeling and regenerative medicine.
September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed non-invasive methods to monitor hair shaft, melanin, and collagen dynamics in C57BL/6 mice across different hair follicle cycle phases, supporting non-invasive research in hair loss treatment development.
November 2024 in “The Journal of Cell Biology” This study revealed that basement membrane dynamics are crucial to hair follicle development, influencing progenitor cell behavior and cell division patterns in developing mouse hair follicles.
October 2018 in “Deep Blue (University of Michigan)” This study found that matrix progenitor cell differentiation in hair growth has distinct early and late phases, and generated a mouse model to explore the hair follicle's role in harlequin ichthyosis.
64 citations
,
January 1995 in “Cells Tissues Organs” This study found that the development and differentiation of Merkel cells in C57BL mouse embryos' dorsolateral skin are linked to tylotrich follicle formation rather than to neural influences.