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The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Aging causes skin stem cells to work less effectively.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

TSH is usually the only test needed to check thyroid function in primary care.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Fullerenes show potential in skin care but need more safety research.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

The document concludes that various clinical methods are used to assess ageing skin and the effectiveness of anti-ageing products.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Key genes are crucial for Drosophila wing development and could be insecticide targets.

Skin grafting is a key procedure for repairing skin defects, with the success depending on the right graft choice, donor site management, and aftercare.

Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.

Mice with human skin protein K8 had more skin problems and cancer.

Primary cicatricial alopecia, a rare disorder causing permanent hair loss, is hard to diagnose and treat, with treatments like anti-inflammatory drugs and steroids offering varied results and no guaranteed cure. Psychological support for patients is important, and future research should aim to identify causes of the condition.