research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
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research Toward Understanding Scarless Skin Wound Healing and Pathological Scarring
Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.
research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth
Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
research Health-Related Quality of Life Among Patients With Alopecia Areata: A Systematic Review
People with alopecia areata, a skin disease, generally have a poor quality of life, especially if more of their scalp is affected.
research Stimulation of Hair Growth by Small Molecules That Activate Autophagy
Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.
research Metabolites From Macroalgae and Its Applications in the Cosmetic Industry: A Circular Economy Approach
Macroalgae compounds offer sustainable, effective benefits for cosmetics.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.
research Characteristics of Stable Isotope Signature of Diet in Tissues of Captive Japanese Macaques as Revealed by Controlled Feeding
More research is needed to understand how diet affects isotope signatures in Japanese macaque tissues.
research The Analysis of Genetics and Associated Autoimmune Diseases in Chinese Vitiligo Patients
Generalized vitiligo in Chinese patients is linked to other autoimmune diseases, especially in familial cases.
research Hair Toxic and Essential Trace Elements in Children with Autism Spectrum Disorder
Children with autism have lower levels of essential and toxic trace elements in their hair.
research New Insights into the Role of Runx1 in Epithelial Stem Cell Biology and Pathology
Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.
research Oxidative Stress in Alopecia Areata: A Case-Control Study
Alopecia areata patients have higher oxidative stress and lower antioxidant levels.
research Androgen Insufficiency in Women: Diagnostic and Therapeutic Implications
Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.
research Possible Protective Effect of Hydroxychloroquine on Delaying the Occurrence of Integument Damage in Lupus: Data from a Multiethnic Cohort
Hydroxychloroquine may help delay skin damage in lupus patients.
research Novel Fish Oil-Based Bigel System for Controlled Drug Delivery and Its Influence on Immunomodulatory Activity of Imiquimod Against Skin Cancer
The fish oil-based gel with imiquimod improves skin cancer treatment and reduces inflammation.
research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 In Vivo
High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.
research Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein
Disulfide bonds make keratin in hair stronger and tougher.
research Do Changes in Chromosomes Cause Aging?
Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.
research Haplotypes Spanning Centromeric Regions Reveal Persistence of Large Blocks of Archaic DNA
Ancient DNA blocks are still present in human genomes, possibly due to advantages they provide.
research Functional Enhancers as Master Regulators of Tissue-Specific Gene Regulation and Cancer Development
Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.
research CD34 Defines Melanocyte Stem Cell Subpopulations With Distinct Regenerative Properties
CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
research Mechanisms Involved in the Relationship Between Vitamin D and Insulin Resistance: Impact on Clinical Practice
Vitamin D might help regulate insulin in the body, but taking Vitamin D supplements doesn't clearly prevent or improve type 2 diabetes. More research is needed.
research Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome
Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.
research A Review of the Evidence for and Against a Role for Mast Cells in Cutaneous Scarring and Fibrosis
Mast cells likely promote skin scarring and fibrosis, but their exact role is still unclear.
research Comparative Genome Analyses Reveal the Unique Genetic Composition and Selection Signals Underlying the Phenotypic Characteristics of Three Chinese Domestic Goat Breeds
Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.
research Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation
The oncoprotein causes abnormal hair growth without increasing skin cancer risk.
research Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization
Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.
research Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors
Thyroid hormone receptors are essential for hair growth and wound healing.
research A Randomized Placebo-Controlled Study on the Effects of Pioglitazone on Cortisol Metabolism in Polycystic Ovary Syndrome
Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.
research Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity
Boosting β-catenin signaling in certain skin cells can enhance hair growth.