January 2024 in “International Journal of Advanced Computer Science and Applications” This review reports that while deep learning shows promise in diagnosing scalp disorders from images, challenges remain with data quality and model interpretability, suggesting that integrating explainable AI techniques is crucial for building trust and facilitating clinical adoption.
December 2023 in “International Journal of Dermatology” This study found an increased risk of asthma and allergic rhinitis in individuals with hidradenitis suppurativa.
September 2023 in “Journal of microbiology and biotechnology” This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.
June 2023 in “Yaghag hoeji” In this study involving rat vibrissa follicles, U. japonica extract was found to enhance hair growth by increasing dermal papilla cell proliferation and accelerating the anagen phase but did not inhibit 5α-reductase activity, which is linked to androgenetic alopecia.
November 2022 in “Molecular Pharmaceutics” This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.
January 2013 in “프로그램북(구 초록집)” This study found that the Hair660™ low-level light therapy device significantly improved hair density and was safe for men with androgenetic alopecia over 24 weeks.
326 citations
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February 2009 in “The American journal of pathology” This review discusses the role of Lgr5 as a marker for identifying adult stem cells, particularly in the intestine and hair follicles, and reports no clinical results.
141 citations
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August 2017 in “Developmental Dynamics” This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.
105 citations
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June 2010 in “The journal of sexual medicine” In this study, female-to-male transsexuals treated with long-acting testosterone undecanoate experienced an increase in lean mass but no change in fat mass or bone mineral density over 24 months.
60 citations
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October 2020 in “Nature Communications” This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.
41 citations
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September 2010 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, hirsute women with normal or medically normalized testosterone levels experienced similar, though declining, hair reduction from both intense pulsed light and long-pulsed diode laser treatments over six months.
35 citations
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December 1979 in “Naunyn-schmiedebergs Archives of Pharmacology” These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
34 citations
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January 2005 in “Journal of the American Veterinary Medical Association” This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.
30 citations
,
November 2018 in “EMBO Reports” This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.
29 citations
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February 2018 in “European Journal of Immunology” In this study, Treg depletion impaired skin wound healing in mice, potentially by altering the cytokine environment and expanding certain T-cell populations, disrupting the normal healing process.
27 citations
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September 2013 in “The FASEB Journal” This study reports that the loss of the protein Memo in mice leads to a reduced lifespan and suggests that Memo is a key regulator of FGFR signaling and vitamin D production.
26 citations
,
January 2012 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This article reviews light-based hair removal devices for home use, highlighting safety issues and the need for consistent international regulations and guidelines for their manufacture and marketing.
18 citations
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February 2017 in “Molecular Medicine Reports” This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.
18 citations
,
October 2015 in “Journal of the European Academy of Dermatology and Venereology” In this study, topical eflornithine reduced hair regrowth in hirsute patients following intense pulsed light therapy, suggesting it may maintain IPL-induced hair reduction over six months.
17 citations
,
November 2009 in “Dermato-endocrinology” This study found that a series of three monthly courses of medium-dose prednisolone pulse therapy was effective and well tolerated in most patients with active, multifocal alopecia areata but not in those with totalis/universalis.
14 citations
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December 2018 in “The American journal of pathology” This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.
12 citations
,
January 2011 in “Current problems in dermatology” This review covers the use of lasers and IPL for hair removal, noting short-term efficacy up to 6 months and variable long-term results with different devices, emphasizing safety considerations and evolving consumer-based treatments.
10 citations
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April 2024 in “International Journal of Molecular Sciences” This study found that patients with alopecia areata had a significantly different gut microbiota composition compared to healthy controls, suggesting possible microbiota involvement in the disease's pathogenesis.
10 citations
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December 2024 in “Allergy” This study found that tralokinumab effectively reduced the severity of moderate-to-severe atopic dermatitis over 28 weeks in adults, with significant improvements in clinical outcomes and biological markers, although 27.4% of patients discontinued treatment due to adverse events or ineffectiveness.
10 citations
,
May 2012 in “PloS one” This study found that non-pigmented hair follicles have significantly lower expression of nucleotide excision repair genes, which may be associated with reduced melanin production capacity in these follicles.
9 citations
,
June 2020 in “BMC Molecular and Cell Biology” This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.
9 citations
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February 2020 in “Journal of Cosmetic Dermatology” In this study, CRH receptor antagonists from Pulsatilla chinensis reversed stress hormone-induced changes in hair follicles and dermal papilla cells in a lab setting, suggesting potential pharmaceutical and cosmetic applications for treating stress-related hair loss.
8 citations
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May 2022 in “Orphanet Journal of Rare Diseases” This study reported that the Undiagnosed Disease Program at Ghent University Hospital successfully provided definite diagnoses for 18% of referred adults with suspected rare diseases, primarily through genomic technologies.
8 citations
,
April 2015 in “Transboundary and Emerging Diseases” This report describes an outbreak of catheter-related infections by ESBL-producing E. coli in calves at an animal teaching hospital, highlighting the risk of these strains becoming nosocomial and increasing mortality and antibiotic use.
8 citations
,
November 2012 in “Blood” This study observed that the incidence of hair loss as a spontaneously reported side effect of novel oral anticoagulant therapy is approximately 4.4 per 100 patient years.