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    Glossary HaCaT keratinocytes

    immortalized human skin cells used in research

    HaCaT keratinocytes are a type of human skin cell that has been immortalized, meaning they can divide indefinitely in laboratory conditions. These cells are commonly used in scientific research to study skin biology, wound healing, and diseases like psoriasis and skin cancer because they closely mimic the behavior of normal human skin cells.

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    1. Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress International Journal of Nanomedicine · 2016 · 43 citations
    2. Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes <i>In Vitro</i> Hormone and metabolic research · 2007 · 24 citations
    3. Anti-oxidant and Anti-inflammatory Effects of Sinapic Acid in UVB Irradiation-Damaged HaCaT Keratinocytes Asian Journal of Beauty and Cosmetology · 2017 · 5 citations
    4. Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes Iranian journal of pharmaceutical research · 2025 · 1 citations
    5. Metabolic pathway of Cis-UCA upon Ultraviolet B (UVB) exposure using ¹H Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Docking and cell viability of human keratinocytes (HaCaT) cell lines UiTM Institutional Repositories (Universiti Teknologi MARA) · 2026
    6. 1316 Aqueous extract of Mentha suaveolens induces Nrf-2 activation and expression of antioxidant and detoxifying enzymes in human keratinocyte HaCaT Journal of Investigative Dermatology · 2018
    7. Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E<sub>2</sub>through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes Biomolecules & therapeutics · 2012 · 9 citations
    8. Therapeutic Effect of Rumex japonicus Houtt. on DNCB-Induced Atopic Dermatitis-Like Skin Lesions in Balb/c Mice and Human Keratinocyte HaCaT Cells Nutrients · 2019 · 20 citations
    9. Regulatory effect of 4-O-methylhonokiol on TGF-β1-induced cell cycle arrest in human keratinocyte cell line (HaCaT) Planta Medica · 2011
    10. The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells Pharmaceuticals · 2021 · 48 citations
    11. HaCaT Cell Proliferation Influenced by Melatonin Skin pharmacology and physiology · 2003 · 28 citations
    12. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing International Journal of Molecular Medicine · 2015 · 23 citations
    13. Vitamin D inhibits captopril-induced cell detachment and apoptosis in keratinocytes 2010 · 8 citations
    14. Differential effects of Wnt5a on the proliferation, differentiation and inflammatory response of keratinocytes Molecular Medicine Reports · 2017 · 6 citations
    15. OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes Antioxidants · 2022 · 6 citations
    16. 874 Elevated expression of osteopontin splice variants in nonmelanoma skin cancer compared to normal skin and adult keratinocytes Journal of Investigative Dermatology · 2018
    17. Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments Open University of Cape Town (University of Cape Town) · 2020
    18. Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia Medicinski arhiv · 2018 · 7 citations
    19. Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes Journal of Cellular Biochemistry · 2015 · 40 citations
    20. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    21. Myrtus communis Leaf Extract Modulates IL-1&alpha; and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing Dove Medical Press (Taylor and Francis Group) · 2026
    22. Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics Scientific Reports · 2022
    23. 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation Journal of Investigative Dermatology · 2017
    24. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    25. Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model Journal of Microbiology and Biotechnology · 2024 · 3 citations
    26. INFLUENCE OF MELATONIN ON HaCaT CELL PROLIFERATION MEASURED BY MEANS OF ATP BIOLUMINESCENCE AND FLUOROMETRIC ASSAYS 2002
    27. Myrtus communis Leaf Extract Modulates IL-1&alpha; and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing SHILAP Revista de lepidopterología · 2026
    28. Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing Clinical Cosmetic and Investigational Dermatology · 2026
    29. Protective Effect of Polysaccharide Derived from Natural Extract on Human Follicle Dermal Papilla Cell and Keratinocytes 2022
    30. Gene expression profiling of human keratinocytes exposed to the hair-dying agent, m-aminophenol 2013