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Skin-derived precursors in hair follicles come from different origins but function similarly.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

Biotin supplements may improve hair and nail growth in people with certain deficiencies or conditions, but there's not enough evidence to recommend it for healthy individuals.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Wnt signaling is crucial for skin wound healing and reducing scars.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Citrullus colocynthis has pain-relieving, anti-inflammatory, antidiabetic, and hair growth benefits, but can cause side effects like colic and diarrhea.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Celiac disease can cause skin problems that may get better with a gluten-free diet.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

Zinc supplements can resolve skin issues caused by zinc deficiency.

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.