research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
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research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance
Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.
research Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway
Hordenine may help hair grow by activating a specific cell growth pathway.
research Hair Growth Effect and the Mechanisms of Rosa Rugosa Extract in DHT-Induced Alopecia Mice Model
Rosa rugosa extract promotes hair growth and could be a natural treatment for hair loss.
research TGFβ and Cancer Metastasis: An Inflammation Link
TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
research ILK Modulates Epithelial Polarity and Matrix Formation in Hair Follicles
ILK is essential for proper hair follicle development and structure.
research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells
PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
research XEDAR Activates the Non-Canonical NF-κB Pathway
XEDAR triggers a specific signaling pathway in cells.
research Recent Updates on Wnt Signaling Modulators: A Patent Review (2014-2020)
New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.
research Promoting Axonal Regeneration Through Exosomes: An Update of Recent Findings on Exosomal PTEN and mTOR Modifiers
Exosomes help nerve fibers grow by affecting specific cell signaling pathways.
research Inhibition of Class I HDACs Preserves Hair Follicle Inductivity in Postnatal Dermal Cells
Inhibiting class I HDACs helps maintain hair growth ability in skin cells.
research Multiple-Wavelength Radiation Promotes Hair Growth by Enhancing the Early Stages of Hair Follicle Development in Human Dermal Papilla Cells and C57BL/6 Mice
Multiple-wavelength radiation helps hair grow by boosting early hair follicle development.
research Potential Role and Therapeutic Interests of Myo-Inositol in Metabolic Diseases
Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.
research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin
Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
research Regulation of Somatic Cell Reprogramming Through Inducible miR-302 Expression
Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.
research Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis
TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
research A Molecular Wound Response Program Associated With Regeneration Initiation in Planarians
Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.
research Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach
Researchers created human hair follicles using a new method that could help treat hair loss.
research WNT Signaling in Disease
The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
research TGF-β Family Signaling in Stem Cells
TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia
Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
research FOXO1, TGF-β Regulation and Wound Healing
FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
research Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing
Wnt signaling is crucial for skin wound healing and reducing scars.
research Activation of Wnt Signaling in Hematopoietic Regeneration
Wnt10b helps blood stem cells grow after injury.
research Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal, and Prostate Cancer
Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.
research Tuning Wnt Signals for More or Fewer Hairs
Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
research Increased Lactate Dehydrogenase Activity Is Dispensable in Squamous Carcinoma Cells of Origin
High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.
research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?
Activating NRF2 might help treat hair disorders by improving antioxidant defenses.
research Role of Stem/Progenitor Cells in Reparative Disorders
Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.
research Role of Beta-Catenin Activation Levels and Fluctuations in Controlling Cell Fate
Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.