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In a keratinocyte-specific knockout mouse model, this study found that deleting GRK2 disrupted hair follicle homeostasis, causing cyst-like structures, abnormal growth patterns, and eventual hair loss, suggesting potential links to immune-mediated alopecias.

Removing GRK2 in skin cells causes hair loss similar to immune-related alopecia.

This study found that GFRα2 influences cell size but not survival or target innervation of Ret-positive low-threshold mechanoreceptors in mouse dorsal root ganglia, differing from its role in nonpeptidergic nociceptors.

This study found that human progenitor keratinocytes form unique complements of enhancers and super-enhancers during differentiation and migration, influencing gene expression and skin disease variant enrichment.

This bibliometric analysis identified SGK1 as a key factor in cancer, showing that its dysregulation can lead to tumor growth and treatment resistance. The authors highlighted SGK1's potential as a therapeutic target, but note that further research is needed to develop effective treatment strategies.

In this study, researchers identified the PLD-mGluR protein in primary mechanosensory terminals as the homomeric GluK2 kainate receptor, functioning purely metabotropically, which is suggested to be common to various sensory endings.

This study discovered that calcium dependent protein kinase 1 (CPK1) directly activates cyclic nucleotide-gated channels 5, 6, and 9, promoting root hair growth in Arabidopsis by regulating Ca²⁺ signaling.

This study explores the role of Lgr6⁺ cells in tissue development and repair across different organs and associates abnormal Lgr6 expression with major diseases, including tumors, noting its potential as a therapeutic target for cancer and other conditions.

This study found that mutant glucocorticoid receptors have defective transcriptional activity and dynamic motility issues in the nucleus, likely due to impaired interactions with nuclear molecules necessary for gene activation.

The researchers reported that hair follicle development and commensal microbe colonization promote the accumulation of regulatory T cells in neonatal skin, with the Ccl20-Ccr6 pathway playing a key role in this process.

This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.

This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.

This study found that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, suggesting a novel signalling pathway in the skin.

This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms.

The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.

This study suggests that using cell-free dexamethasone-primed stem cell media may offer a promising alternative treatment for systemic lupus erythematosus, showing immunomodulatory benefits and therapeutic efficacy in reducing various complications.

This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.

This review examines compounds that activate IK1 channels, highlighting their potential for developing Kir channel agonists and addressing safety concerns, but does not report new experimental findings.

This study found that mice lacking the glucocorticoid receptor in their epidermis showed increased susceptibility to chemical-induced skin cancer, highlighting the receptor's role in skin carcinogenesis.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

Glucocorticoid receptors help regulate genes important for skin health and hair growth.

This study found that the absence of Sgk3 in mice leads to impaired hair follicle maturation, characterized by reduced cell proliferation, increased apoptosis, and premature regression.

This abstract provides a graphic illustrating that mice lacking the Sgk3 gene exhibit thin coats and abnormal hair, suggesting a role for Sgk3 kinase in hair follicle growth, but reports no new experimental findings.

This study found that the transcription factor GLABRA 2 inhibits ethylene production, regulating root hair growth in Arabidopsis under nutrient deficiency conditions.

This study found that KROX20 is crucial for hair follicle development and epidermal homeostasis, as its deletion in skin epithelial cells led to hair loss and increased epidermal thickness.

This paper describes the hGRα gene structure and its expression, focusing on the functional properties of the longest GRα isoform, but reports no new results.

This study found that KSR1 is necessary for v-Ha-ras-mediated skin tumor formation but not for MT-driven mammary cancer, indicating its potential as a therapeutic target in Ras/MAPK signaling-related tumors.

This study identifies specific molecular components involved in the intracellular trafficking of LGR5, revealing mechanisms that differ from typical GPCR recycling processes.

This study indicated that the mineralocorticoid receptor (MR) plays a transient role in regulating epidermal differentiation during late embryonic stages, with glucocorticoid receptor (GR) potentially compensating for MR loss during the perinatal period.