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      Wnt Signaling and Injury Repair

      research Wnt Signaling and Injury Repair

      232 citations , June 2012 in “Cold Spring Harbor Perspectives in Biology”
      This review summarizes the roles of Wnt signaling in wound healing but presents no new clinical findings, suggesting potential for Wnt-based therapies to enhance tissue regeneration.
      Bioengineering Skin Using Mechanisms of Regeneration and Repair

      research Bioengineering skin using mechanisms of regeneration and repair

      202 citations , August 2007 in “Biomaterials”
      This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
      Herbal Therapy in Dermatology

      research Herbal Therapy in Dermatology

      191 citations , February 2002 in “Archives of Dermatology”
      This review discusses herbal therapies for dermatologic disorders, focusing on those with scientific evidence of efficacy and common interactions, but reports no new clinical results.
      Electron Microscope Studies of Hair and Wool

      research ELECTRON MICROSCOPE STUDIES OF HAIR AND WOOL

      191 citations , November 1959 in “Annals of the New York Academy of Sciences”
      This article reports electron microscope studies on the structure of hair and wool, but it does not present new clinical findings.
      Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

      research Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

      178 citations , August 2016 in “Advances in wound care”
      This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.
      Clinical Manifestations of Toxic Shock Syndrome

      research Clinical Manifestations of Toxic Shock Syndrome

      176 citations , August 1981 in “JAMA”
      This study reported that toxic shock syndrome, originally noted in children, is now predominantly associated with menstruating women, with some experiencing recurrence and complications like vocal cord paralysis and impaired finger sensation.
      Zinc Therapy in Dermatology: A Review

      research Zinc Therapy in Dermatology: A Review

      165 citations , January 2014 in “Dermatology Research and Practice”
      This review discusses the various dermatological applications of zinc, including its use in treating infections, inflammatory dermatoses, pigmentary disorders, and neoplasias, and reports no new clinical findings.
      The Human Tri-Peptide GHK and Tissue Remodeling

      research The human tri-peptide GHK and tissue remodeling

      165 citations , January 2008 in “Journal of biomaterials science. Polymer ed.”
      This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
      Hair Follicle Stem Cells: Walking the Maze

      research Hair follicle stem cells: Walking the maze

      165 citations , June 2007 in “European Journal of Cell Biology”
      This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
      Probing the Effects of Stress Mediators on the Human Hair Follicle

      research Probing the Effects of Stress Mediators on the Human Hair Follicle

      159 citations , November 2007 in “American Journal of Pathology”
      In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
      The Pharmacology of Methotrexate

      research The pharmacology of methotrexate

      155 citations , August 1991 in “Journal of The American Academy of Dermatology”
      This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
      Estrogens and Aging Skin

      research Estrogens and aging skin

      150 citations , April 2013 in “Dermato-endocrinology”
      This review discusses the effects of estrogen on skin aging and highlights potential therapies, but reports no new clinical findings.
      The Immune Functions of Keratinocytes in Skin Wound Healing

      research The Immune Functions of Keratinocytes in Skin Wound Healing

      147 citations , November 2020 in “International Journal of Molecular Sciences”
      This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
      Human Skin Stem Cells and the Aging Process

      research Human skin stem cells and the ageing process

      143 citations , September 2008 in “Experimental gerontology”
      This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
      Estrogens and the Skin

      research Estrogens and the skin

      137 citations , June 2005 in “Climacteric”
      This review indicates that estrogen loss during menopause significantly impacts skin health, while estrogen treatment may increase skin collagen, thickness, and elasticity, though effects on other skin characteristics are inconsistent.
      Exosomes for Repair, Regeneration, and Rejuvenation

      research Exosomes for repair, regeneration and rejuvenation

      135 citations , December 2015 in “Expert Opinion on Biological Therapy”
      This review synthesizes recent research on exosomes, highlighting their role as key modulators in regenerative outcomes and suggesting they may offer advantages over stem cell-based therapies in process and regulation.
      The Circadian Clock in Skin

      research The Circadian Clock in Skin

      127 citations , January 2015 in “Journal of Biological Rhythms”
      This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
      Isotretinoin Treatment of Acne and Related Disorders: An Update

      research Isotretinoin treatment of acne and related disorders: An update

      126 citations , October 1983 in “Journal of The American Academy of Dermatology”
      This report verifies isotretinoin's significant efficacy in treating severe acne over the past year in the U.S., highlighting the need for careful patient selection and monitoring due to potential side effects.
      Effect of Aminopterin on Epithelial Tissues

      research EFFECT OF "AMINOPTERIN" ON EPITHELIAL TISSUES

      114 citations , December 1951 in “Archives of Dermatology”
      This article reviews the effectiveness of adrenal cortex compounds E and F in treating various connective tissue disorders and reports no new clinical findings.