60 citations
,
February 1992 in “British Journal of Dermatology” In this study, serum from patients with alopecia areata or universalis did not affect hair growth in transplanted scalp skin grafts on nude mice, despite increased deposition of immunoreactants.
17 citations
,
December 1970 in “Archives of Otolaryngology - Head and Neck Surgery” This study found that human scalp punch autografts were successful in treating scalp alopecia, resulting in long-term hair growth with few hazards observed over 15 years.
This study found that dense-packing hair grafting is a simple, safe, and effective method for restoring scarring alopecia, with high patient satisfaction and significant graft survival rates reported.
2 citations
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July 2013 in “Veterinary dermatology” This study found that hair follicles from dogs with recurrent flank alopecia regenerated and regrew hair when grafted onto mice, suggesting systemic rather than local factors may drive the condition.
61 citations
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February 2003 in “Experimental Dermatology” This study found that increasing dietary soy oil content reduced alopecia areata development in C3H/HeJ mice, though genistein injection showed no significant effect.
18 citations
,
April 2013 in “PLOS ONE” This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.
July 1998 in “Dermatologic Surgery” Various techniques and tools for hair restoration were presented in 1998, including a mathematical model for donor area, use of lasers in surgery, methods for controlling grafted hair direction, and ways to increase graft yield. Satisfaction rates were around 39%, and studies showed trauma and dehydration can damage hair follicles.
82 citations
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March 2016 in “Autoimmunity reviews” This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.
52 citations
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December 2014 in “Journal of Dermatological Science” Apremilast may help treat hair loss in alopecia areata.
16 citations
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November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that intramuscular anti-IFN-γ significantly stabilized and promoted hair regrowth in alopecia areata patients with patchy, progressive hair loss, whereas those with total baldness showed more limited improvement.
11 citations
,
October 2021 in “Stem Cell Research & Therapy” This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.
5 citations
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June 2019 in “British Journal of Dermatology” No results are provided in this article as it lacks an available abstract, making it unclear what effects apremilast and tofacitinib have in a humanized mouse model of alopecia areata.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.
14 citations
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March 2019 in “European journal of pharmaceutics and biopharmaceutics” This study observed that proretinal nanoparticles delivered significantly higher concentrations of retinal to the stratum corneum and hair follicles compared to non-particulate forms, potentially improving topical retinoid therapy.
April 2019 in “Journal of Investigative Dermatology” This study found that post-hematopoietic cell transplantation epidermal grafting significantly reduced chronic wound size in patients with recessive dystrophic epidermolysis bullosa.
January 2007 in “Elsevier eBooks” This article describes the anatomy and life cycle of hair follicles, explaining how disruptions in the hair growth cycle can lead to various forms of alopecia.
2 citations
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March 2006 in “International Society of Hair Restoration Surgery” This article discusses the concept of "donor dominance" in androgenetic alopecia, where grafted hair continues to grow in bald areas, but reports no new clinical findings.
63 citations
,
October 2012 in “Wound Repair and Regeneration” This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.
3 citations
,
May 2011 in “International Journal of Dermatology” In this study, using a 16G epidural needle for preparing the recipient area in hair implantation minimized grafts popping out and resulted in a natural-looking hairline with satisfactory graft survival.
69 citations
,
April 1998 in “Journal of The American Academy of Dermatology” In this study, single hair grafting was reported to be an effective treatment for localized/segmental vitiligo, notably in hairy skin areas, with repigmentation observed in 82% of those cases.
1 citations
,
December 2024 in “The Journal of Dermatology” This study developed mouse models to better understand acquired skin appendage dysfunction, finding that ultra-thin skin grafts maintained stable areas with minimal hair follicles compared to controls, which aids research on skin regeneration therapies.
21 citations
,
February 2015 in “Journal of Feline Medicine and Surgery” This study found that negative pressure wound therapy combined with skin grafting is a feasible method for treating soft tissue and skin defects in cats, achieving a high graft take rate and satisfactory outcomes.
4 citations
,
November 2015 in “Aesthetic Plastic Surgery” Using tissue expanders for scalp reconstruction in patients with extensive Aplasia Cutis Congenita is effective and has minimal complications.
7 citations
,
November 2020 in “Journal of Tissue Viability” In this study, follicular unit extraction grafting using a patient's own scalp follicles showed promise in healing chronic ulcers in a woman with recessive dystrophic epidermolysis bullosa.
In this phase 2 trial, STS01 1% significantly improved hair regrowth in patients with mild to moderate patchy alopecia areata compared to placebo, with a manageable skin irritation side effect profile.
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, 25% of CCHCR1-deficient mice exposed to stress developed hair loss similar to human alopecia areata, suggesting CCHCR1 is a susceptibility gene for the disease.
37 citations
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November 2003 in “Veterinary pathology” This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.
30 citations
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August 2009 in “Journal of the American Academy of Dermatology” This study found that while bimatoprost was safe for 16 weeks, it was not effective for eyelash growth in patients with significant loss due to alopecia areata, though some with less loss experienced growth.
13 citations
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January 2014 in “Journal of Investigative Dermatology” The laser comb did not improve hair regrowth in mice with alopecia areata.
11 citations
,
April 2015 in “EBioMedicine” This research highlights that JAK inhibitors, such as baricitinib, may effectively reverse symptoms of alopecia areata by targeting specific immune pathways, though safety and efficacy require further investigation.