May 2026 in “International Journal of Technology in Education and Science” This study developed a leakage-resistant machine learning framework for classifying hair loss types, emphasizing transparency through explainable AI. Among tested models, Extreme Gradient Boosting excelled, achieving high accuracy and stability on both cross-validation and holdout datasets.
January 2023 in “Methods in molecular biology” This article reviews methods for examining the localization and activity of ROP GTPase, cortical microtubule organization, and F-actin dynamics in plant cell models, but reports no new experimental results.
January 2021 in “Figshare” This study used Density Functional Theory to calculate finasteride's molecular properties, finding the GGA/PW91 method aligns well with experimental data and identifying key reactive sites for chemical interactions.
January 2016 in “Georg Thieme Verlag eBooks” Hair transplantation in East Asians needs special techniques to ensure natural results and prevent complications due to their unique hair and scalp characteristics.
January 2009 in “한국피부장벽학회지” This study reports that in mice, CaR plays a critical role in sensing the epidermal Ca2+ gradient, influencing keratinocyte differentiation, and affecting epidermal development.
September 2005 in “CRC Press eBooks” This study reports that the epidermis is both a source and target for vitamin D3's active form, influencing skin and hair follicle differentiation through a calcium-mediated pathway.
January 2020 in “Química Nova” This study used Density Functional Theory-based computational methods to analyze finasteride's molecular properties, finding that the GGA/PW91 method closely matches experimental data for vibrational frequencies and geometric parameters.
228 citations
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September 2012 in “Trends in Neurosciences” This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.
107 citations
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April 2014 in “The Plant cell” In this study, researchers showed that the CAP1 gene regulates root hair growth in plants by modulating cytoplasmic ammonium levels and maintaining calcium gradients, highlighting its role in ammonium homeostasis.
93 citations
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March 2017 in “Molecular Plant” This study concluded that CNGC14 is a calcium-permeable channel crucial for polarized tip growth in Arabidopsis root hairs, but other channels may also influence the observed calcium influx.
9 citations
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August 2020 in “Journal of The American Academy of Dermatology” This article discusses the therapeutic use of platelet-rich plasma (PRP) in dermatology, specifically its challenges and potential in treating conditions like lichen planopilaris, but reports no new findings.
9 citations
,
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” This paper describes a systematic approach to creating a natural hairline in one session using modern hairline design principles and reports no new clinical results.
April 2025 in “International Journal of Pharmaceutics” Liposomes improve minoxidil delivery to hair follicles, enhancing treatment for hair loss.
January 2025 in “Nature Communications” This study discovered that calcium dependent protein kinase 1 (CPK1) directly activates cyclic nucleotide-gated channels 5, 6, and 9, promoting root hair growth in Arabidopsis by regulating Ca²⁺ signaling.
This study indicates that CD4 protein may have a functional role in basal cell-like keratinocytes through TCR/CD3-independent signaling, affecting their proliferation, differentiation, and migration.
April 2019 in “Progress in Crystal Growth and Characterization of Materials” Hair grows like a crystal at a solid-liquid interface without cell division.
April 2023 in “Journal of Investigative Dermatology” This study found that occlusive dressings on mouse wounds eliminated wound-induced hair neogenesis by upregulating mechanotransduction, which promotes fibrosis, and suppressing Wnt signaling involved in regeneration.
March 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that a positive feedback loop involving RHD2, reactive oxygen species, and calcium ions helps maintain root hair growth sites and influences cell shape in Arabidopsis thaliana.
25 citations
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May 2006 in “Annals of Botany” This study suggests that a tip-focused gradient of intracellular G-actin concentration at the apex is crucial for root hair growth, and maintaining this gradient requires high calcium levels at the root hair tips.
3 citations
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January 2012 in “American Journal of Analytical Chemistry” This study developed and validated a gradient reversed-phase liquid chromatographic method to effectively measure Finasteride and its related impurities in pharmaceutical bulk drugs, demonstrating high linearity and precision.
19 citations
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August 2022 in “Plant Signaling & Behavior” This article reviews how calcium and reactive oxygen species gradients and oscillations interact to promote root hair cell expansion and reports no new experimental findings.
1 citations
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January 1993 in “Skin Pharmacology and Physiology” This study found that an extracellular calcium binding site gradient exists in mouse vibrissa and human scalp follicles, but is not significantly affected by hair growth-altering drugs or epidermal growth factor.
December 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study revealed that Patched receptors establish a Hedgehog signaling gradient in developing hair follicles, which may influence their formation and potentially offer a diagnostic tool for distinguishing Hedgehog-driven tumors.
37 citations
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March 2018 in “Trends in Plant Science” This review discusses the role of reactive oxygen species in regulating oscillating apoplastic pH gradients and growth in plant root hairs and pollen tubes, reporting no new experimental results.
287 citations
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March 1999 in “The Plant Journal” This study found that disrupting the microtubule cytoskeleton in Arabidopsis root hairs caused loss of growth directionality and suggested microtubules interact with calcium gradients to regulate apical growth stability.
47 citations
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August 2014 in “The Journal of Clinical Endocrinology and Metabolism” This study suggests that variations in PCOS phenotypes observed across different ethnic groups may be due to a genetic gradient resulting from historical human migrations and genetic drift.
July 2026 in “arXiv (Cornell University)” In this study, researchers found that the morphology, composition, and elemental enrichment of domestic cat hairs vary significantly along their length, contributing to a functional gradient that affects mechanical properties and challenging assumptions of uniformity in hair structure.
September 2025 in “Psychoneuroendocrinology” This study observed that while hair glucocorticoids were linked to type 2 diabetes, there was no social gradient in glucocorticoid levels among different socioeconomic groups, suggesting these biomarkers may not significantly contribute to understanding socioeconomic health disparities in diabetes.
October 2023 in “Oncotarget” In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.
May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the expression of SLC1A6, a gene linked to calcium gradient and keratinocyte differentiation in the skin, significantly decreases with age, which may contribute to reduced skin barrier function in elderly individuals.