77 citations
,
July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
76 citations
,
July 2006 in “Veterinary Dermatology” In this pilot study, the researchers found that topical application of imiquimod 5% cream may significantly reduce equine sarcoid tumor size, with 80% of tumors showing more than 75% reduction.
65 citations
,
September 2017 in “British Journal of Cancer” In this large British study, prostate cancer risk was linked to ethnicity, family history, prostate enlargement, and PSA testing, while excess adiposity, smoking, diabetes, and certain lifestyle factors were associated with a reduced risk.
58 citations
,
June 2012 in “Journal of Alternative and Complementary Medicine” This review analyzes the traditional Iranian medicine uses of Citrullus colocynthis and compares them with modern phytotherapy findings, reporting no new clinical results but noting safety concerns and dosage considerations.
54 citations
,
October 2019 in “Cochrane library” This study found low- to very low-quality evidence suggesting that several pharmacological treatments, including alpha blockers and antibiotics, may reduce prostatitis symptoms without significantly increasing adverse events in the short term, although more rigorous trials are needed.
49 citations
,
October 2014 in “International Scholarly Research Notices” This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.
48 citations
,
May 2023 in “Nature Communications” In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.
47 citations
,
June 2015 in “Medicines” This review examines the use and efficacy of Panax ginseng in various clinical settings, noting that clinical trial outcomes vary widely based on study conditions and ginseng types; no new results are reported.
46 citations
,
January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.
35 citations
,
April 2014 in “Journal of proteomics” In this study, experimentally induced weight loss in merino sheep led to a decrease in wool fiber diameter and increased expression of certain high sulfur and glycine-tyrosine proteins, potentially impacting wool quality and industry preferences.
34 citations
,
January 2015 in “Biomedicine and Biotechnology” This review discusses how mineral deficiencies, particularly iron and zinc, affect health globally and explores bio-fortification and other strategies to combat these deficiencies, but reports no new experimental results.
31 citations
,
April 2018 in “Royal Society open science” This study found that mange-infected bare-nosed wombats have increased heat loss, higher metabolic rates, altered behavior, and disrupted fatty acid composition compared to healthy individuals.
27 citations
,
July 1946 in “The journal of nutrition/The Journal of nutrition” This study found that adding inositol or biotin to a pig's diet without sulfathalidine had no effect on growth or feed efficiency, but both helped alleviate deficiency symptoms caused by sulfathalidine.
26 citations
,
April 1984 in “The American Journal of Surgery” This study found that gastric exclusion surgery in morbidly obese patients resulted in significant weight loss, improved metabolic parameters, and reduced prevalence of hypertension, diabetes, gout, and hyperlipidemia over time.
25 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that among Japanese women with diffuse hair loss, decreased hair density without changes in vellus hair was the most common and distinct pattern observed, highlighting differences from previous observations in other populations.
23 citations
,
January 2024 in “Nature Immunology” This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.
23 citations
,
February 1979 in “Veterinary Clinics of North America: Small Animal Practice” This review discusses the physicochemical properties, binding mechanisms, and factors affecting corticosteroid-binding globulin (CBG) functions, but reports no new clinical results.
21 citations
,
December 2007 in “Primary Care” This article reviews the challenges in treating PCOS, noting the potential benefits of insulin sensitizers on ovulatory function and pregnancy outcomes, and calls for more long-term studies on metabolic interventions.
20 citations
,
January 2008 in “Journal of Korean Medical Science” This study found that NGAL expression increased in calcium-induced keratinocyte differentiation in vitro and was highly elevated in psoriasis-like skin conditions and skin cancers, suggesting a role in skin hyperplasia and homeostasis.
19 citations
,
May 1992 in “International Journal of Dermatology” This article discusses less commonly used and experimental treatments for vitiligo, focusing on therapies other than psoralen, but does not report new clinical results.
18 citations
,
September 2015 in “Clinical Endocrinology” This study found that women with polycystic ovary syndrome have higher serum VEGF-B levels, which are linked to insulin resistance and decrease after metformin treatment.
18 citations
,
January 2015 in “Journal of obesity and weight loss therapy” This study found that an 8-week low-starch/low-dairy diet led to weight loss, improved insulin sensitivity, and reduced testosterone levels in women with PCOS.
16 citations
,
September 2008 in “American Journal of Orthodontics and Dentofacial Orthopedics” This article reports a case of pressure alopecia caused by wearing headgear, emphasizing the importance of early diagnosis to prevent potential scarring.
16 citations
,
August 2004 in “Tetrahedron” In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.
14 citations
,
January 2024 in “Theranostics” In this study involving a mouse model, researchers reported that intranasal delivery of protein-based CRISPR/dCas9 nanoparticles targeting the gene *Sirt1* reduced cerebral edema and increased survival following ischemic stroke, with no significant toxicity observed.
14 citations
,
April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
13 citations
,
July 2019 in “Toxicology research” In this study, ethanamizuril was found to cause alopecia, biochemical changes, and organ damage at higher doses in rats, with a no-observed-adverse-effect level of 20 mg/kg over 30 days.
12 citations
,
February 2019 in “Skin research and technology” This study found that white hair fibers have lower lipid content and different water absorption dynamics compared to brown hair fibers, suggesting differences in their barrier functions.
12 citations
,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” This review discusses the prenatal care guidelines for women with systemic lupus erythematosus and emphasizes the need for disease activity control to reduce maternal and fetal complications; it reports no new results.
12 citations
,
February 2012 in “New England journal of medicine/The New England journal of medicine” This clinical case report describes a 72-year-old man who experienced significant weight loss and frequent loose stools over eight months, presenting with fatigue.