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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

A woman with breast cancer developed a rare condition causing excessive fine hair growth on her face and body.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

A male with aromatase deficiency improved bone health with estradiol treatment.

Most pregnant women experience skin changes like darkening and stretch marks, and some may have skin conditions that usually get better after giving birth.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

High doses of finasteride cause cell growth and tumors in mice.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Finasteride reduces hair growth and is safe for women with excessive hair.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Women with polycystic ovary syndrome tend to have a longer anogenital distance.

Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Finasteride effectively treats male hair loss, improving growth and density.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Woodhouse-Sakati syndrome often causes sexual development issues, hair loss, learning disabilities, deafness, muscle contractions, limb pain, and diabetes.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.