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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

PCOS is caused by both genetics and environmental factors like diet and obesity.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Low-dose gonadotropin treatment is effective for infertility in women with PCOS, leading to high ovulation rates and comparable pregnancy rates with fewer complications.

Finasteride doesn't affect hormone levels in normal men.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Treatment during development affects hormone balance and sexual behavior in male rats.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.

Cyproterone acetate with ethinyl estradiol is effective for treating skin symptoms related to high androgen levels, like in PCOS.

Irregular menstrual cycles in exercising women may be linked to energy deficiency or hormonal imbalances, requiring careful diagnosis for proper treatment.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Doctors used a special blood sampling technique to diagnose a woman's rare ovarian tumor that was producing male hormones.

Ovulation disorders are a major cause of infertility and menstrual problems in women.

The treatment effectively reduced hair growth and was safe for patients with PCOS, but it needs better bleeding control.

Metformin helps reduce PCOS-related infertility by improving insulin sensitivity and inducing ovulation.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

PCOS may increase the risk of certain cancers.

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.

Inositol was more effective than Metformin in treating symptoms of PCOS in women.

Inositol was more effective than metformin in improving menstrual cycles and pregnancy rates in PCOS patients.

Lifestyle changes like diet and exercise are key for treating overweight women with polycystic ovary syndrome.

Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.