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Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Women with PCOS often have mood disorders and a lower quality of life, and treatment should focus on both physical and mental health.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

Quercetin may help with PCOS symptoms, but more research is needed.

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

The conclusion is that hirsutism should be diagnosed and treated because it affects quality of life and may signal other health problems.

Prolactin may be important for skin growth and immune function.

Some plants used in traditional medicine may help treat cancer because they contain proteins that can inactivate ribosomes.

Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Cyclophosphamide has serious side effects, but long-term follow-up can help manage risks.

Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.

GLI2 increases follistatin production in human skin cells.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

High doses of finasteride cause cell growth and tumors in mice.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.