32 citations
,
September 2018 in “Clinical Obstetrics and Gynecology” This article states that hormone therapy with estrogens and antiandrogens for transgender females is within an obstetrician-gynecologist's practice scope and involves careful dosing and monitoring to manage short-term thrombotic risks.
32 citations
,
January 2018 in “American Journal of Clinical Dermatology” This article provides a framework for understanding hair disorders and treatment options in transgender individuals undergoing hormonal therapy and reports no new clinical results.
31 citations
,
May 2012 in “European Journal of Dermatology” This review examines hair and skin disorders in post-menopausal women and notes a lack of evidence supporting specific treatments for this population.
31 citations
,
September 2006 in “The Journal of Clinical Endocrinology & Metabolism” This article discusses the development of a transdermal testosterone patch for postmenopausal women to deliver physiological testosterone levels but reports no new clinical results, highlighting a need for long-term safety data.
30 citations
,
June 2019 in “Frontiers in Endocrinology” This article discusses the challenges in diagnosing non-classical congenital adrenal hyperplasia and emphasizes personalized treatment approaches, reporting no new clinical results.
30 citations
,
June 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the pathophysiology, genetics, and management of nonclassic congenital adrenal hyperplasia, noting subfertility and hormonal issues without providing new clinical results.
28 citations
,
October 2018 in “Clinical Obstetrics and Gynecology” This study suggests that gender-affirming testosterone therapy in transgender men is generally safe and effective with adequate screening and monitoring, although high-quality long-term studies are lacking.
27 citations
,
March 2018 in “Fertility and Sterility” This study found that in Chinese women with PCOS, pretreatment with ethinylestradiol/cyproterone acetate was associated with a lower risk of gestational diabetes, pregnancy-induced hypertension, and premature delivery compared to those without pretreatment.
27 citations
,
October 2016 in “The Journal of Clinical Endocrinology and Metabolism” In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.
27 citations
,
April 1996 in “Baillière's clinical endocrinology and metabolism” This article discusses the diagnostic complexities of PCOS and emphasizes the importance of differentiating between polycystic ovaries and polycystic ovary syndrome; it presents no new experimental results.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
20 citations
,
July 2009 in “Journal of Pediatric and Adolescent Gynecology” This article reviews various hair abnormalities in adolescents and young adults and emphasizes the importance of timely diagnosis and education for optimal patient outcomes, but it reports no new clinical results.
18 citations
,
September 2018 in “Experimental physiology” This study observed that electro-acupuncture reduced global DNA methylation and DNMT3b expression in a PCOS-like rat model, suggesting a role of hypothalamic DNA methylation in PCOS development and treatment.
18 citations
,
May 2017 in “Fertility Research and Practice” This study found that increased ovarian volume is associated with markers of insulin resistance in women with polycystic ovary syndrome, while follicle number was not linked to metabolic risk.
18 citations
,
January 2009 in “Journal of Endocrinological Investigation” This study concluded that flutamide alone is more effective than finasteride for reducing hirsutism in women, and the combination of both drugs is not superior to flutamide alone.
17 citations
,
August 2019 in “Archives of Cardiovascular Diseases” In this study, the authors observed that testosterone therapy shortened the QTc interval and normalized T-wave morphology in men with acquired LQTS or TdP linked to hypogonadism, suggesting testosterone may be helpful in treatment.
17 citations
,
January 2015 in “MedChemComm” New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.
17 citations
,
May 2012 in “Clinical Endocrinology” This study found that surgical normalization of testosterone in hyperandrogenic women with ovarian androgen-secreting tumors did not significantly change body weight or insulin sensitivity after 12 months.
17 citations
,
February 2003 in “Australasian Journal of Dermatology” This review discusses ovarian hyperthecosis as a rare cause of androgenetic alopecia in postmenopausal women and reports no new results; the authors highlight the need to explore its relationship to alopecia further.
17 citations
,
January 1995 in “The American Journal of Medicine” This review discusses the management of androgenic disorders in women, highlighting that treatment is generally more effective than recognized, though improvement may take weeks or months to appear.
15 citations
,
August 2022 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” This pilot study found that intraovarian platelet-rich plasma administration significantly improved the euploidy rate of embryos in infertile women with previous IVF failures.
15 citations
,
June 2020 in “Experimental Dermatology” This review discusses recent genetic findings on hormonal signaling pathways in androgenetic alopecia, reporting no new study results but highlighting the need for further investigation.
15 citations
,
February 2019 in “Internal Medicine Journal” This study found that experienced Australian prescribers of hormone therapy for transgender adults often follow international guidelines but highlight the need for better training and specific local guidelines.
15 citations
,
August 2016 in “Current Urology Reports” Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.
14 citations
,
January 2008 in “Gynecological Endocrinology” This study reports that in women with non-tumor hyperandrogenism, a decrease in serum testosterone from insulin-sensitizing therapy like metformin may indicate a low likelihood of having an androgen-secreting tumor.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.
13 citations
,
January 2016 in “Journal of cosmetology & trichology” This review discusses the emerging pathophysiological factors and potential new therapies for androgenetic alopecia beyond traditional treatments, but reports no new results.
13 citations
,
June 1989 in “Pediatric clinics of North America/The Pediatric clinics of North America” This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.
12 citations
,
January 2009 in “Gynecological Endocrinology” This case report identified ovarian hyperthecosis as the cause of recent-onset androgenic symptoms in a 73-year-old woman, which was confirmed by ovary removal and led to symptom improvement.