research Slow Progress in Prostate Cancer
Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.
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research Ovarian Hyperthecosis in Adolescent Females: Two Case Reports and a Review of the Literature
Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.
research A Case of Ovarian Hyperthecosis in a Postmenopausal Woman
A postmenopausal woman's excess male hormone symptoms improved after her ovaries were removed.
research Insights into Ovarian Hyperandrogenism: Lessons from Two Unusual Cases
The study found that imaging might miss small ovarian tumors causing high testosterone, and suggested using certain testosterone levels and treatment responses to identify these tumors.
research Hyperandrogenism After Menopause
A postmenopausal woman's increased male hormone levels were successfully treated with surgery.
research Update on Medical Management of Benign Prostatic Hyperplasia
Castration is preferred for non-breeding male dogs with BPH, but other treatments are available with specific pros and cons.
research Vaginal Bleeding in Pre-Pubertal Females
Recurrent vaginal bleeding in young girls without puberty signs may require a genital exam to find hidden causes.
research A Rare Cause of Hyperandrogenism in Postmenopausal Women: Ovarian Stromal Hyperplasia
Ovarian stromal hyperplasia can cause high testosterone in postmenopausal women and is treated by removing the ovaries.
research Intratesticular Control of Steroidogenesis
The testes control steroid production through complex interactions involving various cells and signaling molecules.
research Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)
Nafarelin may effectively treat excessive hair growth in women by reducing certain hormone levels.
research Interventions for Hirsutism Excluding Laser and Photoepilation Therapy Alone: Abridged Cochrane Systematic Review Including GRADE Assessments
Some medications can reduce excessive hair growth in women, but more research is needed to find the best treatment combinations.
research Diagnosis and Therapy of Hyperandrogenism
Most women with too much androgens have PCOS, which can be managed with birth control pills, medication for hair growth, and fertility treatments, and losing weight helps too.
research Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women
Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.
research Surgery of Solitary Vestibular Schwannomas
Cyproterone acetate is a safe treatment that causes modest feminization in transgender female adolescents, and works better with added estrogens.
research Central Precocious Puberty Secondary to Peripheral Precocious Puberty Due to a Pineal Germ Cell Tumor: A Case and Review of Literature
A pineal tumor caused a boy's early puberty, which changed from peripheral to central after treatment.
research Female Pelvic Conditions: Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects about 10% of women, is often linked to obesity and family history, and can cause irregular periods, fertility issues, and other symptoms. It's usually managed with lifestyle changes, weight loss, and medication.
research Ovarian Hyperthecosis Coexisting with an Incidental Adrenal Lesion: Challenges in the Diagnostic Approach
Using GnRHa agonists helps diagnose and treat ovarian hyperthecosis when surgery isn't possible.
research Hirsutism, Acne, and Hair Loss: Management of Hyperandrogenic Cutaneous Manifestations of Polycystic Ovary Syndrome
Effective treatment for skin issues in women with PCOS includes oral contraceptives, antiandrogens, and other medications and procedures.
research Neural Substrates of the Emotional Negativity Bias as Revealed by Hemodynamic Data
Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.
research Polycystic Ovary Syndrome: Current Evidence and Practical Recommendations
The document concludes that more research is needed to include new treatments in guidelines for Polycystic Ovary Syndrome (PCOS).
research Expression of AKT1 Along with AKT2 in Granulosa-Lutein Cells of Hyperandrogenic PCOS Patients
The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
research Effects of Finasteride, a 5 Alpha-Reductase Inhibitor, on Circulating Androgens and Gonadotropin Secretion in Hirsute Women
Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.
research Status of Sex Reassignment Surgery for Gender Identity Disorder in Japan
In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.
research Time Lags Between Various Maturity Measures and Spermarche
Certain maturity signs appear before and after the first release of sperm in boys.
research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.
research Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial
Spironolactone most effective for hirsutism, but has side effects.
research An Integrative View of Mammalian Seasonal Neuroendocrinology
The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.
research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.
research Polycystic Ovary Syndrome: Early Detection in Adolescents
Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.
research Prolonged Treatment with Finasteride (a 5α-Reductase Inhibitor) Does Not Affect Bone Density and Metabolism
Long-term finasteride use doesn't change bone density or metabolism.