10 citations
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July 2023 in “Pharmaceutics” In this study using mice and human keratinocyte cells, researchers found that activating PKM2-mediated glycolysis and Wnt/β-catenin signaling, particularly via combined treatments, significantly accelerated wound healing and induced angiogenesis in wound beds.
3 citations
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June 2025 in “Drug Design Development and Therapy” This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.
November 2025 in “Phytomedicine” This study identified rhamnose as a compound that promotes hair growth by enhancing glycolysis and stimulating hair follicle regeneration, highlighting its potential use in alopecia treatment through animal and human organ culture models.
This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.
January 2024 in “Figshare” Activating autophagy in hair follicle stem cells can lead to hair growth and repair by affecting sugar metabolism.
June 2023 in “Research Square (Research Square)” This study found that autophagy activation in hair follicle stem cells shifted their metabolism to glycolysis, which promoted hair growth by initiating the hair follicle cycle.
This study identified specific lncRNAs and mRNAs differentially expressed in miniaturized follicles compared to normal follicles in patients with androgenetic alopecia, with AL136131.3 potentially inhibiting hair growth and accelerating follicle transition to catagen through effects on glycolysis-related genes.
April 2018 in “Journal of Investigative Dermatology” In this study, researchers found that stabilizing the protein HIF1A in hair follicles promotes glycolysis over oxidative phosphorylation, potentially reducing oxidative stress and supporting hair growth.
April 2023 in “Journal of Investigative Dermatology” This study found that overexpression of the lncRNA AL136131.3 may inhibit hair shaft growth and promote hair follicle apoptosis in androgenetic alopecia by influencing key metabolic pathways.
June 2025 in “Proceedings of the National Academy of Sciences” In this study, a mouse model with a PIK3CA gain-of-function mutation in Schwann cells revealed unique communication with neighboring cells and a glycolytic shift in peripheral nerves, and early alpelisib treatment significantly improved symptoms, though efficacy declined with delayed administration due to limited drug penetration.
April 2019 in “Journal of Investigative Dermatology” Stabilizing HIF1A in hair follicles may boost hair growth by enhancing energy production and blood vessel formation.
19 citations
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September 1971 in “Journal of Investigative Dermatology” 4 citations
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January 2021 in “Current Research in Physiology” This study found that high levels of μ-crystallin in skeletal muscle are associated with greater fat metabolism and a shift in gene expression towards slower muscle function.
3 citations
,
July 2025 in “Stem Cell Research & Therapy” This study highlights the potential of extracellular vesicles derived from HuMSCs and lncRNA VIM-AS1 to enhance wound healing in diabetic conditions, suggesting innovative strategies for tissue repair.
71 citations
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June 1993 in “Journal of Investigative Dermatology” 
202 citations
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August 2017 in “Nature cell biology” This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.
133 citations
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November 2018 in “Aging” This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.
100 citations
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November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.
36 citations
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January 2019 in “Nature communications” This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.
19 citations
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December 2018 in “Experimental and Molecular Medicine” This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.
14 citations
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May 2017 in “Cell metabolism” This study found that glycolysis in Paneth cells provides lactate to support mitochondrial oxidative phosphorylation in intestinal stem cells, aiding their function and differentiation.
11 citations
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August 2024 in “Nature Communications” In this study, researchers observed that quiescent mouse embryonic fibroblasts showed reduced glycolysis but increased TCA cycle flux and mitochondrial respiration, with these changes linked to metabolic reprogramming involving yes-associated protein inhibition and malate cycle modulation, which supports extracellular matrix protein synthesis.
8 citations
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April 1965 in “Archives of biochemistry and biophysics” This study found that sheep wool follicles actively oxidize acetate and glucose, suggesting the involvement of the TCA cycle for compound synthesis and the potential role of the pentose phosphate pathway in ribose production for RNA and DNA.
7 citations
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July 2025 in “Nature Communications” In this study using mice, researchers found that the Piezo1 channel regulates metabolic changes and immune cell infiltration during skin growth under tension, with altered expression of glycolysis-related genes and increased macrophage activity observed in stretched skin.
6 citations
,
March 2020 in “Scientific reports” This study found that glucose metabolism supports hair inductive gene expression and hair shaft elongation in dermal papilla cells, suggesting potential applications for in vitro hair follicle generation.
4 citations
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February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.
2 citations
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December 2022 in “Pharmaceutics” This study found that activating both PKM2 and Wnt/β-catenin signaling pathways significantly enhanced hair regrowth and hair follicle neogenesis in mice, suggesting a potential strategy for treating alopecia.
This study found that periodic red light exposure in aged mice increased histone acetylation and activated metabolic processes in keratinocytes, mitigating cellular aging through enhanced fatty acid oxidation and altered gene expression related to lipid metabolism.
This study found that periodic red light exposure increased histone acetylation and activated metabolic processes in aged mice, leading to enhanced fatty acid oxidation and the mitigation of cellular aging by influencing gene expression and metabolic regulation.