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    Glossary Glutaminolysis

    metabolic process breaking down glutamine for energy and growth

    Glutaminolysis is a metabolic process where the amino acid glutamine is broken down to produce energy and other molecules that cells need to grow and function. This pathway is particularly important in rapidly dividing cells, such as cancer cells, which rely on glutaminolysis to meet their increased energy and biosynthetic demands.

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    1. Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Journal of Investigative Dermatology · 1993 · 71 citations
    2. Human hair growth in vitro: a model for the study of hair follicle biology Journal of Dermatological Science · 1994 · 133 citations
    3. Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation Nutrients · 2018 · 18 citations
    4. The nutritional biochemistry of wool and hair follicles 2000 · 14 citations
    5. 651 Epigenetic regulation of macrophage activity by glutamine during wound healing Journal of Investigative Dermatology · 2024
    6. Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma bioRxiv (Cold Spring Harbor Laboratory) · 2023
    7. 266 Glycogen metabolism and Cori cycle in human hair follicles 2017
    8. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    9. Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase Scientific Reports · 2021 · 30 citations
    10. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    11. Regulatory T Cells: the Many Faces of Foxp3 Journal of Clinical Immunology · 2019 · 125 citations
    12. Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential International Journal of Molecular Sciences · 2019 · 75 citations
    13. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    14. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    15. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    16. Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation Nutrients · 2018 · 19 citations
    17. Hair Growth Promoting Effect of <i>Hottuynia cordata</i> Extract in Cultured Human Hair Follicle Dermal Papilla Cells Biological & Pharmaceutical Bulletin · 2019 · 16 citations
    18. The role of multiomics in revealing the mechanism of skin repair and regeneration Frontiers in Pharmacology · 2025 · 4 citations
    19. Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets Pharmaceutical Research · 2025 · 2 citations
    20. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    21. Noval advance of histone modification in inflammatory skin diseases and related treatment methods Frontiers in immunology · 2024
    22. Culture of the human pilosebaceous unit, hair follicle and sebaceous gland Experimental Dermatology · 2018 · 30 citations
    23. Advances in Understanding Hair Growth F1000Research · 2016 · 28 citations
    24. Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of l-cystine and vitamin B6 Archives of Dermatological Research · 2012 · 11 citations
    25. Evaluation of Animal Models Suitable for Hair Research and Regeneration InTech eBooks · 2018 · 3 citations
    26. Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth Nature Communications · 2025
    27. Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Nutrients · 2022
    28. 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss Journal of Investigative Dermatology · 2021
    29. Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation Frontiers in Immunology · 2025 · 5 citations
    30. Activity of hair tonic preparation combining Apium graveolens L extract, Tussilago farfara flower extract, Achillea millefolium extract, Cinchona succirubra bark extract on male New Zealand white rabbits JURNAL ILMU KEFARMASIAN INDONESIA · 2024