Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study analyzed the geometric and electronic properties of baicalin conformers, finding that BCLa2TT and BCLa1TT conformers exhibit high stability in aqueous solutions and are favorable for interactions with positively charged species.

This study found that in women with acne vulgaris, lower serum levels of 3α-androstanediol-glucuronide suggest reduced 5α-reductase activity compared to controls, indicating that 5α-reductase inhibitors may not be effective for acne treatment.

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

This study found that pregnancies with gestational diabetes in a Midwestern U.S. cohort demonstrated elevated androgen levels compared to healthy controls, suggesting a common relationship between impaired glucose tolerance and hyperandrogenemia across diverse ethnic backgrounds.

This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.

This study found that metformin treatment during pregnancy in women with PCOS was associated with higher SHBG levels in newborns, but did not affect androgen or estrogen levels at birth.

This study identified a series of novel β-glucuronidase inhibitors that may help mitigate adverse effects of first-line anti-cancer drugs by targeting gut bacteria, based on virtual high-throughput screening findings.

This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.

This review discusses the importance of androgen production and metabolism in hyperandrogenism, the use of specific serum markers for diagnosis, and the need for improved assays for clinical testing, but reports no new results.

This review discusses diagnostic and treatment considerations for women with cutaneous hyperandrogenism, noting therapeutic options are more effective for hirsutism and acne than for androgenetic alopecia, but reports no new clinical results.

This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.

This review outlines diagnostic possibilities for diffuse, nonscarring hair loss in women and reports no new clinical findings.

This study found that androsterone glucuronate (ADT-G) was the only androgenic metabolite sensitive to detecting differences between adult women with acne and controls, and its levels decreased with systemic treatment.

This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This review discusses the steroidogenic properties of human skin and suggests that impaired steroidogenesis may be linked to conditions like acne, rosacea, atopic dermatitis, and androgenic alopecia, but reports no new clinical results.

This article reviews the characteristics and classification of SAHA syndrome and its relationship with other conditions, without presenting new clinical findings.

This review examines the physiological role of androgen conjugates in cutaneous androgen metabolism and questions their association with hirsutism, without presenting new clinical findings.

This study observed that ethyl glucuronide (EtG) concentrations in hair decreased significantly during an abstinent period, suggesting possible wash-out effects or other factors affecting EtG levels.

This study suggests that chest, arm, leg, and beard hair samples may be viable alternatives to scalp hair for monitoring long-term alcohol intake, although body hair is more typically collected from men.

This review discusses the potential of using human hair proteomics for non-invasive diagnostic and forensic applications but reports no new results; the authors highlight areas needing further research.

This study concluded that finasteride, cyproterone acetate, and flutamide were similarly effective at reducing hirsutism in women, though they acted through different mechanisms.

This chapter reviews the causes and underlying steroid pathways of hirsutism and virilization in women, detailing relevant conditions and laboratory assays without reporting new clinical results.

This study used metabolomics to identify distinctive metabolic and phenolic profiles in American ginseng (Panax quinquefolius) from various regions, revealing specific biomarkers that can help differentiate between ginseng from Northeast China, Shandong, and the United States.

This study developed and validated a comprehensive method using mass spectrometry to profile sex (pro)hormones in plasma, with results showing reliable calibration and detection of 31 analytes in samples from pre- and postmenopausal women and men, while addressing potential over- or underestimations in analyte concentrations.

This study found that different species metabolized minoxidil into various products, with monkeys and humans showing similar profiles primarily excreting a glucuronide conjugate, while rats and dogs showed distinct differences.

This review discusses the multifactorial etiology of hypospadias, including genetic predispositions and possible environmental factors, and highlights the need for further studies on genetic and environmental contributions to its increasing prevalence, without presenting new findings.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

This review discusses the classifications, diagnostic methods, and treatment strategies for female pattern hair loss, but reports no clinical results.

This review traces the historical understanding and treatment of acne across ancient Egyptian, Greek, and Roman civilizations, but provides no new clinical findings.