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Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Excess androgens may cause PCOS, not just be a symptom.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Dogs with sex hormone imbalances may not drink or pee a lot but often lose hair on their body and can have reproductive system issues.

Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

People with Parkinson's disease have higher levels of cortisone in their hair, which may indicate chronic stress hormone dysfunction.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Excessive body hair in women can be caused by various conditions and treated with medication like Diane® 35 or androgen blockers.

A woman's excessive hair growth around a leg ulcer was linked to a treatment with Prostaglandin E1 ointment.

Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

A woman's excessive hair growth was caused by a rare benign tumor in her adrenal gland, which was successfully removed.