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This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.

This study found that among users of glucagon-like peptide-1 receptor agonists, semaglutide and tirzepatide were associated with higher incidences of hair loss, particularly androgenetic alopecia and telogen effluvium, with rapid weight loss identified as a potential contributor to telogen effluvium.

This review examines current evidence on personalized management strategies for PCOS, but does not present new clinical results; the authors advocate for treatments tailored to predominant symptoms and individual health profiles.

This narrative review explores how psychological stress may contribute to premature skin aging by affecting dermal collagen and elastin remodeling through neuroendocrine, molecular, and cellular pathways, highlighting potential therapeutic targets to preserve skin structure and function.

This study reviews advances in targeted therapies for moderate-severe dermatological conditions like plaque psoriasis and atopic dermatitis, reporting on newly approved treatments and highlighting the need for further innovations in managing rare inflammatory skin diseases through emerging laboratory techniques and trials.

This study reported that visceral massage improved skin elasticity and metabolic indicators such as glucose and lipid levels, suggesting its potential as a non-invasive method for enhancing skin health and systemic metabolism.

This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.

In this case study, a woman with congenital adrenal hyperplasia experienced substantial improvement in musculoskeletal and neurobehavioral symptoms after low-dose testosterone therapy, highlighting its potential role in managing chronic glucocorticoid overtreatment effects.

This study observed that methylene blue, a mitochondrial-targeted antioxidant, promotes hair follicle stem cell proliferation and viability through reduced oxidative stress and enhanced β-catenin signaling, and it may also protect against hair loss related to glucagon-like peptide-1 receptor agonists by reducing metabolic stress.

This retrospective study at the University Clinical Centre in Gdańsk reported that 77.9% of patients with alopecia areata were treated with off-label pharmacotherapy, predominantly glucocorticosteroids, highlighting a reliance on these therapies in European clinical practice.

This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.

This study found that cis-urocanic acid can engage in non-enzymatic reactions with reactive sulphur species, forming new metabolites, and suggests sulphide donors may protect against UVB-related toxicity.

This systematic review reports that HAIR-AN syndrome, characterized by severe insulin resistance, hyperandrogenism, and distinctive skin issues, significantly impacts obese women and can improve with treatments like metformin, emphasizing the importance of targeted management to reduce metabolic complications.

In this case report, the researchers documented two instances of melasma linked to finasteride use, highlighting the need for clinicians to review medication history when treating facial hyperpigmentation, especially in individuals with darker skin types.

This review identified significant associations between glucose dysregulation and various dermatological conditions like psoriasis and acne, suggesting that dietary interventions and probiotics may help manage related inflammation, highlighting the need for holistic treatment approaches for insulin resistance and metabolic syndrome.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This study found that individuals with a recent history of suicide attempts exhibited altered DHEA hair levels, suggesting possible dysregulation of the HPA axis as a biopsychosocial feature, and recommends further investigation into hair hormones as potential markers of suicidal crisis and vulnerability.

This review summarizes recent literature on using metformin to treat polycystic ovary syndrome, discussing its benefits and potential drawbacks, and reports no new clinical results.

This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.

This case report describes a rare and severe systemic reaction to red tattoo ink, including erythroderma, alopecia universalis, anhidrosis, and vitiligo, highlighting significant diagnostic and therapeutic challenges.

This analysis reports no significant differences between spironolactone and metformin for managing PCOS, noting spironolactone remains a potential off-label option for patients unable to use hormonal contraceptives, but larger studies are necessary to confirm its efficacy.

This study suggests that using combined oral contraceptives does not increase hair glucocorticoid levels, but hair treatments should be considered as a confounder in stress biomarker assessments.

This case study suggests a potential connection between insulin resistance-induced diabetes and the development of migraine symptoms in a patient with HAIR-AN syndrome, highlighting the importance of early diagnosis and a multifaceted treatment approach.

This review suggests weak associations between GLP-1 receptor agonists and increased reports of hair loss, particularly with semaglutide and tirzepatide, while cases of hair regrowth were also occasionally documented.

This case report presents a patient with idiopathic isolated ACTH deficiency and testicular germ cell tumor, with alopecia areata as an initial symptom, suggesting a potential link between these conditions.

This study highlighted cases where children with atypical forms of celiac disease exhibited symptoms like recurrent alopecia and seborrhea, emphasizing the need for timely diagnosis and treatment to optimize outcomes.

This study found that regulatory T cells accumulate in hair follicle epithelium via the Cxcr4-Cxcl12 axis, partially influenced by glucocorticoid receptor signaling, promoting hair regeneration; similar mechanisms were observed in human and murine skin.

In this case study, a 69-year-old woman with severe hypercortisolism developed acute adrenal insufficiency after starting ketoconazole treatment, highlighting the need for cautious dosing and close monitoring of adrenal function, particularly in patients with prior glucocorticoid exposure.

This article aims to guide aesthetic practitioners on conducting thorough nonsurgical hair restoration consultations by understanding hair growth cycles and the causes of hair loss, including those from specific medications and conditions like Long COVID.

In this study, cats fed trace minerals complexed with lysine and glutamic acid displayed temporary improvements in hair loss and dander scores at 45 days, compared to those receiving inorganic trace minerals, although no differences were seen by day 90.