July 2026 in “Journal of Investigative Dermatology” GLP-1 therapies can cause hair loss, but hair often regrows after stopping or reducing the drug.
July 2026 in “Journal of the American Academy of Dermatology” GLP-1 and GLP-1/GIP agonists may increase the risk of hair loss.
April 2026 in “Open MIND” This review article discusses the aesthetic impacts of GLP-1 medications like Ozempic (semaglutide), including "Ozempic Face," skin sagging, and loss of lean mass, and explores potential recovery methods such as biostimulators, HIFU, endolaser, and PRP.
January 2026 in “Skin Appendage Disorders” This study found that hair shedding occurs in seven out of ten users of GLP-1 receptor agonists in real-world settings, a much higher prevalence than in clinical trials, which affects treatment adherence, especially among women experiencing significant weight loss.
May 2024 in “International Journal of Dermatology” This research highlights the lack of clinical evidence linking GLP-1 agonists, commonly used in treating type 2 diabetes and obesity, to hair loss, despite theoretical concerns regarding potential hair health impacts.
1 citations
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January 2025 in “ARC Journal of Dermatology” This study suggests that among GLP-1 agonists, liraglutide and exenatide are linked to the highest rates of gastrointestinal issues, including potentially pancreatitis-related enzyme changes noted in animal models.
February 2026 in “JAAD International”
37 citations
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March 2006 in “Regulatory Peptides” This study reports that GLP-1 receptors and proglucagon are expressed in the skin of newborn mice, with GLP-1 potentially playing a role in skin development and hair follicle formation.
31 citations
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January 2025 in “Journal of the American Academy of Dermatology” GLP-1 RA medications may be linked to hair loss.
24 citations
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June 2011 in “Andrologia” This study found that Ganoderma lucidum extracts reduced prostate enlargement and improved symptoms in testosterone-treated rats, suggesting potential benefits for managing benign prostatic hyperplasia.
20 citations
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August 2022 in “Archives of Medical Science” This publication discusses the 2021 ESC Guidelines for the prevention of cardiovascular disease in clinical practice and reports no new results.
12 citations
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June 2024 in “JAAD Case Reports” Tirzepatide may improve hair loss by reducing insulin resistance.
4 citations
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March 2025 in “Journal of Cosmetic Dermatology” This study highlights a potential association between semaglutide, a diabetes medication, and increased reports of hair loss, with researchers calling for more rigorous clinical trials to confirm and better understand the risk.
3 citations
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September 2025 in “Frontiers in Cardiovascular Medicine” This study reports that women with polycystic ovary syndrome, especially those with a hyperandrogenic pattern, are at a higher risk for cardiovascular disease compared to other PCOS patients, likely due to related metabolic comorbidities.
2 citations
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December 2022 in “Journal of Clinical Medicine” This review suggests that, among non-hormonal treatments for menstrual irregularities in adolescents with PCOS, metformin is the most effective and cost-efficient option, particularly in overweight adolescent girls.
1 citations
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October 2025 in “Journal of Personalized Medicine” This review discusses various weight loss treatment options for managing PCOS in women, including lifestyle changes, diet, medications, and surgery, but reports no new clinical results.
1 citations
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March 2025 in “Journal of Investigative Dermatology” Metabolic issues may trigger lymphocytic cicatricial alopecia, and treatments targeting these issues could help.
August 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This narrative review suggests that the association between weight-loss medications and telogen effluvium is primarily due to metabolic changes from rapid weight loss, rather than a direct pharmacological effect on hair follicles.
June 2026 in “International Journal of Innovative Technologies in Social Science” This review explores how metabolic and psychological factors contribute to binge eating disorder in women with PCOS and highlights the need for non-punitive, comprehensive management strategies.
May 2026 in “Reviews in Endocrine and Metabolic Disorders” This review explores weight loss interventions during gestation, emphasizing incretin-based therapies' potential to enhance reproductive health and address metabolic changes for better maternal and fetal outcomes.
May 2026 in “International Journal of Innovative Technologies in Social Science” This review reports that lifestyle modification, including diet and exercise, is essential for managing PCOS, while pharmacological and complementary treatments address specific symptoms like menstrual irregularities and insulin resistance.
March 2026 in “Frontiers in Medicine” This study reviews advances in targeted therapies for moderate-severe dermatological conditions like plaque psoriasis and atopic dermatitis, reporting on newly approved treatments and highlighting the need for further innovations in managing rare inflammatory skin diseases through emerging laboratory techniques and trials.
February 2026 in “Editora Pasteur eBooks” This abstract does not report specific research results but introduces a book focusing on the intersection of endocrinology and aesthetic medicine and its growing importance in contemporary clinical practice.
January 2026 in “Quality in Sport” This review observed that semaglutide may have therapeutic benefits for skin conditions like psoriasis and hidradenitis suppurativa, but reports of adverse skin reactions exist, indicating the need for further research to understand its safety and efficacy in dermatology.
In this case study, a patient developed a rash consistent with acute generalized exanthematous pustulosis after increasing the dose of semaglutide, suggesting that the reaction was likely due to the excipient propylene glycol, highlighting the importance of ingredient analysis and multidisciplinary collaboration for patient safety.
July 2025 in “Scientific Reports” In this study, peptide nanofiber gels RG and RJ significantly accelerated the healing of deep second-degree burn wounds in vivo, with greater wound closure rates and enhanced tissue regeneration compared to controls, attributed to increased angiogenesis and reduced systemic inflammation.
May 2025 in “International Journal of Women’s Dermatology” In this retrospective cohort study, researchers found that exposure to 5-alpha reductase inhibitors and spironolactone in female alopecia patients was not linked to an increased risk of developing malignant or benign gynecologic tumors when compared to minoxidil use.
February 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study observed an increased risk of alopecia areata among new users of GLP-1 agonists semaglutide and liraglutide compared to users of bupropion-naltrexone, highlighting potential hair loss concerns with these medications.
January 2025 in “Journal of the European Academy of Dermatology and Venereology” The study by Godfrey et al. highlights a potential link between GLP-1 receptor agonists, specifically semaglutide and tirzepatide, and the risk of alopecia, emphasizing the need for further investigation and patient awareness.
December 2024 in “Cureus” This case report describes significant symptom improvement and hair regrowth in a man with recalcitrant folliculitis decalvans after starting tirzepatide for weight management, suggesting a potential new therapy avenue.