research Targeting Smoothened for Therapeutic Gain
Targeting the Smoothened receptor shows promise for treating certain cancers.
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60-86 / 86 resultsresearch Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans
Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.
research Azelaic Acid Stimulates Catalase Activation and Promotes Hair Growth Through Upregulation of Gli1 and Gli2 mRNA and Shh Protein
Azelaic acid helps protect hair cells from UV damage and encourages hair growth by increasing certain gene expressions and proteins.
research Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology
The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.
research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog
Activating the Sonic hedgehog gene in mice can start the hair growth phase.
research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer
The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
research Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice
Inhibiting ornithine decarboxylase may help prevent certain skin cancers.
research Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice
Targeting ornithine decarboxylase can help prevent skin cancer.
research Role of FGFR2-Signaling in the Pathogenesis of Acne
Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
research Sostdc1 Defines the Size and Number of Skin Appendage Placodes
Sostdc1 controls the size and number of hair and mammary gland structures.
research The Vitamin D Receptor as Tumor Suppressor in Skin
Vitamin D and its receptor may help prevent skin cancer.
research Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep
Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.
research SOX9 in Organogenesis: Shared and Unique Transcriptional Functions
SOX9 is essential for the development of various organs and hair follicles.
research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis
GLI1 might protect against the start of skin cancer and is not linked to cancer severity.
research Expression of Signaling Components in Embryonic Eyelid Epithelium
Eyelid cells share signaling components but differ in pathway activity.
research Evo Devo of the Vertebrate Integument
The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.
research Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits
Genes affecting wool fiber thickness in Angora rabbits were identified, which could help breed finer wool.
research Ptch2 Is a Potential Regulator of Mesenchymal Stem Cells
Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.
research Non-Histone Methylation of SET7/9 and Its Biological Functions
SET7/9 enzyme affects cell growth and diseases like cancer, diabetes, and obesity.
research Stabilization of Epithelial Beta-Catenin Compromises Mammary Cell Fate Acquisition and Branching Morphogenesis
Keeping β-catenin levels high in mammary cells disrupts their development and branching.
research Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration
Immune cells are essential for skin regeneration using biomaterial scaffolds.
research Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
Genes linked to wool fineness in sheep have been identified.
research Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells
Certain natural products may help stimulate hair growth by affecting stem cell activity in the scalp.
research Forensic DNA Phenotyping
Forensic DNA Phenotyping accurately predicts physical traits and is used in investigations, but needs more diverse population data for confirmation.
research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
research Novel Insights Into the Pathways Regulating the Canine Hair Cycle and Their Deregulation in Alopecia X
The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.