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    Glossary GLI1

    gene involved in cell growth and development signaling

    GLI1, or Glioma-associated oncogene homolog 1, is a gene that encodes a protein involved in the Hedgehog signaling pathway, which is crucial for cell growth and development. Abnormal activation of GLI1 can lead to uncontrolled cell proliferation and is associated with various cancers, including gliomas.

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    Research 30 of 368

    1. GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter Journal of Investigative Dermatology · 2004 · 171 citations
    2. Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors Annals of Dermatology · 2014 · 8 citations
    3. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    4. Utility of GLI1 RNA Chromogenic in Situ Hybridization in Distinguishing Basal Cell Carcinoma From Histopathologic Mimics Modern Pathology · 2023 · 3 citations
    5. Rare Gli1+ perivascular fibroblasts promote skin wound repair bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    6. Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein. PubMed · 2020 · 1 citations
    7. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    8. Keloid pathogenesis and fibroproliferative properties are dependent on stem cells regulated by the HEDGEHOG-GLI1 pathway Research Square (Research Square) · 2023
    9. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 380 citations
    10. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 333 citations
    11. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    12. Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways Cosmetics · 2025
    13. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature · 1997 · 638 citations
    14. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy Cancers · 2021 · 11 citations
    15. WISP-1 induced by mechanical stress contributes to the fibrosis and hypertrophy of ligamentum flavum via the Hedgehog-Gli1 signaling 2020
    16. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    17. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog Journal of Clinical Investigation · 1999 · 231 citations
    18. Epithelial stem cells and implications for wound repair Seminars in Cell & Developmental Biology · 2012 · 156 citations
    19. Keratin 17 in disease pathogenesis: from cancer to dermatoses Journal of pathology · 2018 · 62 citations
    20. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin Aging Cell · 2009 · 62 citations
    21. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013 · 52 citations
    22. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    23. 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    24. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    25. Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X PLOS ONE · 2017 · 18 citations
    26. Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease Cell Reports · 2022 · 14 citations
    27. Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages Experimental Cell Research · 2014 · 14 citations
    28. Stem Cells from Human Exfoliated Deciduous teeth Promote Hair Regeneration in Mouse Cell Transplantation · 2021 · 12 citations
    29. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    30. Alpinetin promotes hair regeneration via activating hair follicle stem cells Chinese medicine · 2022 · 11 citations