83 citations
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July 1993 in “Journal of the American Veterinary Medical Association” This study found that surgical removal of adrenal glands resolved clinical signs of adrenocortical tumors and hyperplasias in ferrets, but cortisol levels were not excessively high.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that sebaceous gland atrophy in psoriatic lesions correlates with the down-regulation of specific lipid biosynthetic gene modules, potentially affecting hair appearance without damaging follicles.
4 citations
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January 2017 in “Acta dermato-venereologica” A new EDA gene mutation was found in a Chinese family with a specific skin disorder.
April 2019 in “Journal of Investigative Dermatology” This study found that induced COX-2 expression in adult transgenic mice led to hair follicle miniaturization and enlargement of sebaceous glands, and suggests that targeting the PGD2 pathway might reverse these effects.
April 2017 in “Journal of dermatological science” This study found that while epidermal PLCγ1 is not necessary for keratinocyte differentiation in interfollicular epidermis, it is crucial for normal hair and sebaceous gland formation in mice.
This study found that men with benign prostate hyperplasia showed increased meibomian gland dysfunction and tear film instability compared to age-matched controls, and were also more likely to have androgenic alopecia.
October 2017 in “Chinese Journal of Dermatology” 36 citations
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August 2022 in “Frontiers in Cell and Developmental Biology” This article reviews the aging process of sebaceous glands, highlighting the role of intrinsic and extrinsic factors on their degradation and reporting no new clinical findings.
16 citations
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July 2012 in “Current pharmaceutical biotechnology” This review discusses the pathogenesis of common sebaceous gland diseases and their molecular pathways, but it reports no new clinical findings.
9 citations
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December 2002 in “Novartis Foundation Symposium” In this research, LEF1 was identified as a crucial transcription factor for submucosal gland development in mouse and ferret tracheas, though it requires other factors to induce gland formation.
3 citations
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May 2016 in “Dermatopathology” The researchers reported that Lrig1 overexpression was observed in 100% of sebaceous carcinoma cases, suggesting it may serve as a potential marker for poorly differentiated sebaceous carcinoma.
181 citations
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January 2019 in “Cell” In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.
April 2023 in “Journal of Investigative Dermatology” This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.
47 citations
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January 1998 in “Molecular Carcinogenesis” This study observed that targeted expression of the neu oncogene in transgenic mice led to significant epidermal hyperplasia and a carcinoma-like appearance, suggesting a crucial role for erbB2 signaling in epidermal proliferation and carcinogenesis.
42 citations
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July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.
13 citations
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July 2009 in “Pediatrics in Review” This review discusses the diagnosis and treatment of 21-hydroxylase deficiency in congenital adrenal hyperplasia and emphasizes the need for earlier detection and proper management; it reports no clinical results.
7 citations
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February 2021 in “Dermatologic Therapy” This review discusses various pathologies involving sebaceous glands, primarily and secondarily, but reports no new clinical findings.
2 citations
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May 2011 in “International Journal of Dermatology” This case report details a 12-year-old boy from rural south India diagnosed with syringolymphoid hyperplasia, which presented with alopecia and anhidrosis.
October 2023 in “Journal of the Endocrine Society” This case report highlights the potential benefits of unilateral adrenalectomy in treating primary bilateral macronodular adrenal hyperplasia, noting a high rate of remission and low risk of recurrence.
September 2023 in “International Journal of Community Medicine and Public Health” This source reviews a range of sebaceous gland disorders, exploring their clinical characteristics, risk factors, and common treatments, including conditions such as sebaceous gland hyperplasia and acne vulgaris, and highlighting various therapeutic approaches.
14 citations
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September 1983 in “Acta Dermato Venereologica” This study found that daily topical application of citral increased sebaceous gland lobules and cell hyperplasia in male rats after three months.
11 citations
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August 2000 in “Journal of Endocrinology” In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.
1 citations
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August 2022 in “Veterinary medicine and science” This review discusses various diagnostic and treatment strategies for canine prostate diseases, including pharmacological options and advanced procedures, but reports no new clinical results.
3 citations
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May 1990 in “Journal of Steroid Biochemistry” This study found that diagnosing non-classical 3 beta-hydroxysteroid dehydrogenase deficiency solely based on elevated serum or urinary 5-ene-steroids may not be reliable.
November 2021 in “Pharmaceutical Sciences” This study found that the compound androstane-17-carboxamide 6 may serve as a lead for new drugs to treat BPH and prostate cancer by reducing the weight of androgen-dependent glands.
3 citations
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January 2018 in “Reproduction, Fertility and Development” This study concluded that cyproterone acetate alone produced antiandrogenic effects on the female gerbil prostate, while ethinyloestradiol alone stimulated estrogenic activity, and their combination led to prostatic lesions.
September 2020 in “Current Enzyme Inhibition” In this study, researchers found that steroidal 17β-carboxamides 1-4 significantly inhibited 5α-reductase enzyme activity and reduced prostate weight more effectively than finasteride in a hamster model, without toxic side effects, suggesting potential for treating benign prostatic hyperplasia.
201 citations
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May 2001 in “Proceedings of the National Academy of Sciences” This study found that transgenic expression of COX-2 in mouse basal keratinocytes causes epidermal hyperplasia and certain dysplastic features at specific body sites.
101 citations
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June 2003 in “The EMBO Journal” Phospholipase Cδ1 is crucial for normal skin and hair development.
76 citations
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May 2011 in “Cell death and differentiation” This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.