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Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Noggin is necessary to start the hair growth phase in skin after birth.

Lactate production is important for activating hair growth stem cells.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Hair loss in men is common, treatable, but not curable.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Aging causes skin stem cells to work less effectively.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Male pattern baldness involves hormones and cell signals affecting hair growth.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.