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GlossaryGrowth Factors (GF)

naturally occurring proteins that regulate cell growth and repair

Growth factors are naturally occurring proteins or hormones that play a crucial role in regulating cell growth, proliferation, and differentiation. They are essential for various biological processes, including wound healing, tissue repair, and hair growth. In the context of hair, growth factors can stimulate hair follicles, promoting the growth of new hair and potentially aiding in the treatment of conditions like alopecia.

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Expression Patterns of Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Their Cognate Receptors GFRα-1, GFRα-2, and Common Signal Transduction Element c-Ret in Human Skin Hair Follicles

research Expression Patterns of Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Their Cognate Receptors GFRα-1, GFRα-2, and Common Signal Transduction Element c-Ret in Human Skin Hair Follicles

18 citations, January 2008 in “Journal of The American Academy of Dermatology”

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.

research Identification and Characterization of an Antisense RNA Transcript (GFG) from the Human Basic Fibroblast Growth Factor Gene

24 citations, July 1994 in “Molecular Endocrinology”

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

research Analysis of Skin Graft Survival Using Green Fluorescent Protein Transgenic Mice

19 citations, January 2007 in “Journal of medical investigation”

GFP transgenic mice help study cell origins in skin grafts.

research Reawakening GDNF's Regenerative Past in Mice and Humans

1 citations, April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

research Revitalizing Hair Growth: A New Regimen Utilizing Growth Factor Concentrate for Hair Loss Treatment

June 2024 in “Cureus”

GFC injections significantly improved hair growth and quality with minimal side effects.

The Effect of Human Lyophilized Growth Factors Versus Platelet Rich Plasma Injection on Hair Transplantation Outcome in the Crown Area of the Scalp in Men With Androgenetic Alopecia

research The Effect of Human Lyophilized Growth Factors Versus Platelet Rich Plasma Injection on Hair Transplantation Outcome in the Crown Area of the Scalp in Men With Androgenetic Alopecia

February 2024 in “Research Square (Research Square)”

Both PRP and L-GF treatments improved hair transplant results, with L-GF being slightly better, but the difference was not significant.

research Folliscope Assessment of Lyophilized Growth Factors Scalp Injection in Androgenetic Alopecia

October 2021 in “QJM: An International Journal of Medicine”

L-GF injections improved hair growth in women with minimal side effects.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations, December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

77 citations, February 2017 in “Stem Cell Reports”

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Beta-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes During Post-Traumatic Gliogenesis in the Adult Brain

research Beta-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes During Post-Traumatic Gliogenesis in the Adult Brain

67 citations, December 2009 in “Stem Cells”

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

research Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8

61 citations, May 2016 in “Scientific reports”

The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.

research Cutaneous and Mucosal Manifestations Associated with Celiac Disease

57 citations, June 2018 in “Nutrients”

Celiac disease can cause skin problems that may get better with a gluten-free diet.

research Extra-Intestinal Manifestation of Celiac Disease in Children

54 citations, June 2018 in “Nutrients”

Early diagnosis and a strict gluten-free diet are crucial for children with celiac disease to improve symptoms.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

37 citations, September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Dietary Glucoraphanin Prevents the Onset of Psychosis in Adult Offspring After Maternal Immune Activation

36 citations, January 2018 in “Scientific reports”

Eating glucoraphanin can help prevent psychosis in offspring whose mothers had immune system activation.

research Gene Delivery to the Hair Follicle

34 citations, September 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Gene therapy shows promise for treating hair loss by targeting hair follicles.

research Development of Gene Therapy for Inner Ear Disease: Using Bilateral Vestibular Hypofunction as a Vehicle for Translational Research

28 citations, January 2011 in “Hearing Research”

Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24

25 citations, August 2007 in “Molecular Therapy”

Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.

research Therapeutic Efficacy and Safety of a 1927-nm Fractionated Thulium Laser on Pattern Hair Loss: An Evaluator-Blinded, Split-Scalp Study

21 citations, January 2018 in “Lasers in Medical Science”

The 1927-nm fractionated thulium laser treatment significantly improves hair thickness and count in pattern hair loss patients.

research Niche Required for Inducing Quiescent Stem Cells

19 citations, January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology”

A special environment is needed to fully activate sleeping stem cells.

research Long-Term Time-Lapse Multimodal Intravital Imaging of Regeneration and Bone Marrow-Derived Cell Dynamics in Skin

18 citations, September 2013 in “Technology”

The study introduced a new imaging technology to track skin healing and bone marrow cell activity over time.

research Effect of the 5α-Reductase Enzyme Inhibitor Dutasteride in the Brain of Intact and Parkinsonian Mice

16 citations, October 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Dutasteride may protect the brain in early Parkinson's disease.

research Rejuvenation of the Male Brow

12 citations, July 2008 in “Facial Plastic Surgery Clinics of North America”

The document concludes that careful planning and consideration of male brow anatomy are essential for successful facial rejuvenation with cosmetic surgery.