33 citations
,
May 2016 in “Translational andrology and urology” This review examines hair removal practices prior to genital gender affirming surgery, noting current variations and offering a practical laser hair removal approach, but reports no new clinical results.
86 citations
,
March 1993 in “Toxicology and Applied Pharmacology” Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.
45 citations
,
April 2018 in “Nature Reviews Urology” This review discusses the molecular mechanisms of masculinization involving androgen signaling and their roles in male embryonic development and conditions like hypospadias and prostate cancer, and reports no clinical results.
24 citations
,
November 2023 in “International Journal of Molecular Sciences” This review highlights that platelet-rich plasma and adipose-derived stem cell therapy may offer safe and promising improvements for managing symptoms of genital lichen sclerosus, with a potential synergistic benefit when combined.
21 citations
,
December 2015 in “Development Growth & Differentiation” This study introduces genital sex differentiation parameters (GSDP) to analyze sexual differences in external genitalia and perineum development in mice, revealing varied sensitivity to androgen inhibition in genital structures.
18 citations
,
March 2004 in “The Journal of Urology” In this study, researchers used a hypospadiac rat model to demonstrate abnormal genital development, similar to human penoscrotal hypospadias, highlighting the model's value for studying penile growth and differentiation.
10 citations
,
January 2018 in “Dermatology online journal” This review describes the surgical and nonsurgical genital rejuvenation options for addressing hair, morphology, and vascular changes, noting increased interest but providing no new clinical findings.
3 citations
,
January 2019 in “PubMed” This article discusses the use of platelet-rich plasma in genital rejuvenation and reports no new clinical results, suggesting further research is needed to evaluate its effectiveness in this area.
1 citations
,
May 2019 in “The Journal of Sexual Medicine” This case report describes two women experiencing hormonally associated vestibulodynia and female arousal disorder, potentially linked to the use of spironolactone for androgen-mediated cutaneous disorders.
May 2024 in “Indian Dermatology Online Journal” This study reports a case of trichobacteriosis pubis, a rare bacterial infection causing malodour in the pubic region, which improved with hair trimming and topical clindamycin, subsequently enhancing the patient's sexual relationship.
April 2022 in “Australasian Journal of Dermatology” This case report describes a rare presentation of recurrent plaque psoriasis on the penile shaft, which was controlled with systemic therapy after topical treatments failed.
May 2019 in “Australasian Journal of Dermatology” A new diagnostic tool for Vulvovaginal Lichen Planus is highly accurate, and updated treatments for various skin conditions, including melanoma and Hidradenitis Suppurativa, were discussed.
April 2017 in “Australasian Journal of Dermatology” Different skin conditions show distinct types of vessel inflammation, a new quality of life index for vulval disease is reliable, a certain intrauterine system might be linked to chronic vaginal yeast infections, and oral minoxidil reduces hair loss in women.
This study found that finasteride treatment in adult hamsters led to significant testicular alterations and reduced spermatogenesis compared to untreated controls.
122 citations
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July 1990 in “Teratology” This study found that oral administration of finasteride to pregnant rats caused dosage-related developmental toxicities, including hypospadias and decreased anogenital distance in male offspring.
62 citations
,
June 2015 in “Sexually Transmitted Infections” This study identifies sexual activity as a significant potential transmission route for Trichophyton interdigitale, causing tinea genitalis among travelers to South East Asia.
5 citations
,
January 2024 in “Reproductive Medicine and Biology” In this review, extensive analysis using conditional mutant mice revealed that androgen and Wnt signals play crucial roles in the development and function of male external genitalia and erectile tissue, while also exploring various regulatory factors involved in their pathogenesis.
December 2024 in “Journal of Coloproctology” This study presents a case of a 67-year-old immunocompromised woman with ulcerated genital and perianal lesions diagnosed as herpesvirus-induced dermatovirosis, highlighting the importance of considering viral infections in differential diagnoses and the potential for resistance to typical antiviral treatments.
May 2021 in “Journal of Advances in Internal Medicine” This case report describes a 13-year-old with DSD raised as female, exhibiting hoarseness and clitoral enlargement, with hormonal assessments not indicating common related deficiencies.
1 citations
,
January 2006 in “Maia-rivista Di Letterature Classiche” This review discusses the bioactive compounds and biological activities of Polygonum multiflorum Thunb. and highlights concerns about its hepatotoxicity, but reports no new clinical results.
10 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found a high prevalence of genital Lichen sclerosus and autoimmune comorbidities in patients with frontal fibrosing alopecia, suggesting a possible shared autoimmune process.
3 citations
,
February 2024 in “Wound Repair and Regeneration” In this systematic review, researchers examined the occurrence and treatment of penile keloids and found that circumcision is a common trigger, particularly in prepubescent children. Despite various therapeutic approaches, penile keloids are rare, complicating further study of this condition.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Older people often have untreated genital skin diseases due to embarrassment and lack of medical attention, which can lead to discomfort and even cancer risk.
15 citations
,
December 2019 in “Aesthetic Surgery Journal” This study found that there is a low prevalence and wide variability in U.S. insurance coverage for ancillary gender surgeries, with specific criteria often required for favorable coverage.
51 citations
,
August 2012 in “Differentiation” This study found that penile and clitoral differentiation in mice is influenced by androgen exposure, with penile features developing postnatally requiring prenatal and ongoing androgen presence.
50 citations
,
August 1985 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This study found that spironolactone directly inhibits 5 alpha-reductase activity in hirsute women, resulting in decreased conversion of testosterone to dihydrotestosterone, which may contribute to its therapeutic effects.
November 2025 in “SKIN The Journal of Cutaneous Medicine” This study aims to assess the real-world effectiveness of baricitinib, a JAK inhibitor, for promoting regrowth of nasal, genital, and beard hair in patients with severe alopecia areata, expanding on findings from the BRAVE-AA clinical trial. Results are not reported.
21 citations
,
July 2004 in “British Journal of Dermatology” This study suggests that hair follicles in the genital area may serve as reservoirs for high-risk human papillomaviruses.
12 citations
,
December 2011 in “Canadian Journal of Microbiology” In this study, all five serotypes of Ureaplasma were found to be pathogenic in a mouse model of lower genital tract infection, with serotype 4 showing the greatest pathogenicity.
4 citations
,
December 2022 in “Skin Research and Technology” This study found that downregulation of Sonic hedgehog signaling may promote HPV replication and wart formation by inducing cell cycle arrest in keratinocytes.