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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Medical castration in prostate cancer patients can increase the risk of serious heart rhythm problems, so it's important to monitor heart activity during treatment.

Hair loss in children is diagnosed and treated differently than in adults, with different common causes and a focus on less invasive methods.

Minoxidil is effective for hair growth and safe for long-term use.

The review suggests new ways to classify ejaculation problems and recommends different treatments based on the type of issue.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

Norwegian puffin dogs have a unique type of hair loss that often doesn't get better on its own and responds well to ciclosporin treatment.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

Hirsutism in women is often due to hormone sensitivity and has significant psychological effects.

Gene expression in hair follicles can help diagnose methamphetamine use disorder.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

A woman was diagnosed with porphyria cutanea tarda and improved with phlebotomy and lifestyle changes.

Follicle Stimulating Hormone is important for fertility.

SLE and DM can coexist but are rare and need careful evaluation.

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.

Men with severe early-onset baldness may have worse heart artery function and stiffer arteries if they have high blood pressure.

Zouboulis syndrome is a rare condition that helps diagnose monosomy 18p early.

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

An 87-year-old woman was diagnosed with type 3 autoimmune polyendocrine syndrome and had multiple autoimmune issues.

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

Removing β-catenin in certain stem cells causes hair whitening and pigmentation issues.

Mild essential fatty acid deficiency can cause health issues and is worsened by low-fat diets.

The document concludes that PCOS in adolescents is complex and requires comprehensive care to manage its symptoms and associated health risks.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.