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A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

Higher sebum levels are linked to more severe male baldness.

MOF controls skin development by regulating genes for mitochondria and cilia.

Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.

The gene Prss53 affects hair shape and bone development in rabbits.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.

No link between hair loss and blood groups or Rhesus factor.

Dermal stem cells help regenerate hair follicles and heal skin wounds.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.