4 citations
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June 2015 in “Journal of Genetics/Journal of genetics” This abstract reports funding sources for ongoing research and does not present any study results.
April 2023 in “Journal of Investigative Dermatology” This study found that sebaceous glands can regenerate after PPARg deletion in adult skin, relying on the hair cycle and FGFR signaling.
81 citations
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May 2019 in “Frontiers in Endocrinology” This study found that administering melatonin for 12 weeks to women with PCOS significantly reduced hirsutism, testosterone, and inflammation markers, while enhancing antioxidant levels compared to a placebo.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
290 citations
,
December 2017 in “Journal of The American Academy of Dermatology” This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.
222 citations
,
January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.
175 citations
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November 2009 in “PLOS ONE” This study found that both genetic and environmental factors influence appearance-related aging in women, with skin wrinkling, hair graying, and sun damage significantly affecting perceived age more than chronological age.
162 citations
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October 2014 in “Autoimmunity reviews” This review discusses alopecia areata, highlighting its autoimmune aspects, environmental triggers, and current treatment options, but reports no new clinical results; recent studies suggest JAK pathway intervention may offer therapeutic potential.
157 citations
,
July 2001 in “British Journal of Dermatology” In this study, the prevalence of androgenetic alopecia among Korean men and women was found to be lower than in caucasians, with Korean men showing more frontal hairline preservation and a higher incidence of 'female pattern' hair thinning.
150 citations
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October 2010 in “The American Journal of Pathology” This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.
148 citations
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December 2018 in “Journal of autoimmunity” This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
139 citations
,
December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
122 citations
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April 2020 in “American Journal Of Pathology” This review discusses the multiple factors contributing to skin aging, including cellular changes and environmental influences, and highlights its recognition as a disease with significant implications beyond cosmetic concerns, without reporting new research results.
117 citations
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November 2006 in “Experimental Dermatology” This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.
113 citations
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June 2019 in “F1000Research” This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.
104 citations
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May 2019 in “F1000Research” This review discusses recent research on male infertility causes and treatments, emphasizing the need for further understanding of idiopathic sperm abnormalities and molecular factors to improve patient outcomes; it reports no new clinical results.
77 citations
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March 2001 in “Clinics in Dermatology” This article discusses treatment approaches for female pattern hair loss and concludes that available medical treatments are effective in reversing or stabilizing the condition in most cases of mild-to-moderate severity.
75 citations
,
June 1999 in “Pediatric Clinics of North America” This review discusses the clinical features and therapeutic goals for teenagers with PCOS, emphasizing the need for further research into its causes and potential long-term health risks, but reports no new clinical results.
62 citations
,
March 2008 in “American Journal of Human Genetics” This study located a potential genetic link for androgenetic alopecia on chromosome 3q26, marking an early step in identifying new susceptibility genes for male pattern baldness.
56 citations
,
October 2016 in “Journal of dermatological science” This review explores multidisciplinary advances in understanding alopecia areata, including epidemiology, pathogenesis, and innovative treatments, but reports no new research results.
53 citations
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January 2013 in “Journal of toxicologic pathology” This publication provides a standardized nomenclature for classifying microscopic lesions in laboratory rat and mouse skin, aiming to harmonize international toxicological research.
50 citations
,
July 1996 in “Cell” This review discusses genetic and epigenetic mechanisms that may contribute to aging and presents models suggesting that chromosomal changes could play a key role in the aging process; it reports no new experimental findings.
45 citations
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May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
44 citations
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April 2012 in “American Journal of Clinical Dermatology” Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
44 citations
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January 2005 in “Dermatology” This article reviews the clinical and diagnostic features of hair shaft disorders, emphasizing the role of structured patient assessments and the avoidance of hair trauma, but reports no new results.
40 citations
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July 2016 in “Pediatrics in review” This article reviews puberty's onset, development, and the factors affecting it, including nutrition, obesity, and gender dysphoria, and reports no new clinical results.
39 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.
38 citations
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October 2006 in “Fertility and Sterility” The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.
37 citations
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January 2019 in “JAMA Dermatology” This study found a bidirectional relationship between major depressive disorder and alopecia areata, with each condition significantly increasing the risk of subsequently developing the other.
37 citations
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October 2014 in “Maturitas” This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.