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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Inactive hair follicle stem cells help prevent skin cancer.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

Children with atopic dermatitis often have sleep problems due to itching and may benefit from melatonin, which helps with sleep and skin symptoms.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Zinc can both inhibit and stimulate mouse hair growth, and might help recover hair after chemotherapy.

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Both mouse and rat models are effective for testing alopecia areata treatments.

SHBG may be a useful early indicator and treatment target for PCOS.

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Celiac disease can cause skin problems that may get better with a gluten-free diet.

Improving the environment and cell interactions is key for creating human hair in the lab.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

Finasteride helps reduce heart issues and improves heart function.