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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

PCOS is caused by both genetics and environmental factors like diet and obesity.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Sulforaphane from broccoli can help protect skin from sun damage.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.