2 citations,
May 2021 in “Stem Cells International” Human pluripotent stem cells could be used to make platelets for medical use, but safety, effectiveness, and cost issues need to be resolved.
1 citations,
January 2024 in “International journal of molecular sciences” TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.
1 citations,
November 2022 in “Diagnostics” A woman with a rare hormone resistance condition also had missing teeth and hair loss, which might be new symptoms of her genetic disorder.
The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.
February 2021 in “Journal of Investigative Dermatology” Hair loss in male pattern baldness is linked to changes in specific genes and proteins that affect hair growth and scalp health.
127 citations,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
41 citations,
April 2019 in “PLOS genetics” CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
January 2024 in “Biomedicines” The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.
October 2022 in “Frontiers in Genetics” The research found new potential mechanisms in mouse hair growth by studying RNA interactions.
224 citations,
February 2013 in “The Journal of clinical investigation/The journal of clinical investigation” ERG increases SOX9, promoting prostate cancer growth and invasion.
8 citations,
September 2022 in “Human genomics” Key genes and pathways involved in thyroid eye disease were identified, aiding potential treatment and diagnosis.
65 citations,
September 2014 in “Orphanet Journal of Rare Diseases” The study identified three mutations in the STUB1 gene in two families with autosomal recessive cerebellar ataxia (ARCA) and cognitive impairment, revealing significant clinical heterogeneity. Using homozygosity mapping and exome sequencing, researchers found a homozygous missense variant (c.194A > G, p.Asn65Ser) in three siblings and a compound heterozygous mutation (c.82G > A, p.Glu28Lys and c.430A > T, p.Lys144Ter) in another patient. Functional studies showed that these mutations impaired CHIP’s ubiquitin ligase activity and reduced CHIP levels in patient fibroblasts. Clinical symptoms varied widely, including diabetes, alopecia, uveitis, and ulcerative colitis, underscoring the complexity of genotype-phenotype correlations in STUB1-related ataxias.
98 citations,
March 2019 in “Frontiers in immunology” Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.
100 citations,
December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
98 citations,
May 2016 in “Genes” The review discussed significant progress in understanding wool keratin-associated proteins (KAPs) in sheep, which are crucial for wool fiber structure. Advances in sequencing allowed for the categorization of KAPs into families, identification of gene polymorphisms, and understanding of their chromosomal locations and gene expression characteristics. Genetic variation in KAP genes was linked to wool traits, offering potential for selective breeding to enhance wool quality. The review highlighted the complexity of KAPs, noting that 27 different KAP family members had been identified, though further research was needed to confirm these findings and explore unidentified ovine KAP genes.
2 citations,
February 2022 in “BioMed Research International” LED light therapy at 863 nm wavelength can slow down skin tumor growth and reduce inflammation in mice.
Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.
23 citations,
July 2020 in “Aging Cell” Aging changes sugar molecules on skin stem cells, which may affect their ability to repair skin.
14 citations,
December 2018 in “The American journal of pathology” Activating Nrf2 in skin cells speeds up wound healing by increasing the growth of certain stem cells.
10 citations,
November 2018 in “The Italian Journal of Pediatrics/Italian journal of pediatrics” Early diagnosis of Trichorhinophalangeal syndrome type 1 is crucial for treatment and was achieved through clinical examination and family history.
9 citations,
August 2021 in “International journal of molecular sciences” PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
8 citations,
July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.
6 citations,
November 2015 in “Experimental dermatology” Adenine helps delay aging in human hair follicle cells.
5 citations,
November 2022 in “Genetics selection evolution” Low-coverage sequencing is a cost-effective way to find genetic factors affecting rabbit wool traits.
1 citations,
November 2023 in “BMC chemistry” Tadalafil and Finasteride may help treat aggressive melanoma.
December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” EAAT4 decreases with age, harming skin function and calcium balance.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.
January 2022 in “Sustainable development goals series” The document concludes that significant investment in agricultural innovation is necessary to achieve global food security and nutrition.
426 citations,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
321 citations,
January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.