This study found that GPC1 is a key regulator of angiogenesis in human dermal microvascular endothelial cells, influenced by factors secreted by keratinocytes, and may be a target for alopecia treatment research.
4 citations
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August 2023 in “Journal of Cosmetic Dermatology” Gynostemma pentaphyllum extract may help grow hair and prevent graying.
April 2016 in “Journal of Investigative Dermatology” This study provides a comprehensive platform to explore stem cell interactions regulating hair follicle growth, revealing key signaling pathways in epithelial-mesenchymal interactions using advanced RNA sequencing and transgenic reporters.
3 citations
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January 2005 in “Biological & Pharmaceutical Bulletin” This study reports that the peptide GPIGS, found in Bacillus sp. M18 conditioned medium, may promote hair growth through the PI-3K/Akt pathway and accelerate hair regrowth in mice.
This study found that GPC1 is a significant regulator of angiogenesis in human dermal microvascular endothelial cells, suggesting its potential as a target for alopecia research.
The researchers found that melatonin implantation in Cashmere goats influenced PDGFA gene expression and hair growth cycles, indicating it may control hair phase transformation from growth to catagen and telogen.
4 citations
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August 2025 in “Bőrgyógyászati és Venerológiai Szemle” This study applied a novel method to the Italian economy and found that declining labor productivity from 1981-2004 was mostly due to a fall in total factor productivity growth.
This study found that GPC1 plays a crucial role in regulating angiogenesis in human dermal microvascular endothelial cells, which may make it a potential target in alopecia treatment research.
68 citations
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November 2012 in “Journal of Investigative Dermatology” This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.
12 citations
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April 2019 in “Scientific Reports” This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.
1 citations
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April 2016 in “Journal of Investigative Dermatology” This study identified that blocking the PTGDR2 receptor in human hair follicles in vitro and in mice reversed the hair growth inhibition caused by PGD2, suggesting a potential approach for treating alopecia.
This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.
280 citations
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January 2004 in “The EMBO Journal” AGC2-1 protein is essential for root hair growth in Arabidopsis.
January 2024 in “Biological & pharmaceutical bulletin” In this study, Panax ginseng extract and its ginsenosides were found to stimulate the proliferation of hair-related cells and promote the transition from the telogen to the anagen phase, enhancing hair-shaft growth by suppressing BMP4 expression in human dermal papilla cells.
11 citations
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May 2016 in “Naunyn-Schmiedeberg's Archives of Pharmacology” This study found that 15-dPGJ2 promotes apoptosis in human follicular keratinocytes, suggesting its potential role in developing hair loss prevention treatments through DP2 antagonism.
18 citations
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February 2018 in “International Journal of Molecular Sciences” This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.
4 citations
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February 2025 in “Nutrients” This randomized controlled trial found that consuming *Gynostemma pentaphyllum* extract significantly improved hair elasticity, density, and diameter over 24 weeks without severe adverse events, suggesting it as a safe functional food ingredient for hair health improvement.
July 2021 in “Archives of Dermatological Research” This study found that serum GPER-1 levels were significantly higher in patients with androgenetic alopecia compared to healthy controls, suggesting a potential role in the condition's pathogenesis, independent of gender.
18 citations
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June 2017 in “Proceedings of the National Academy of Sciences of the United States of America” In this mouse study, hair growth defects associated with the Gk5 null allele were partially alleviated by simvastatin treatment, suggesting GK5 plays a key role in skin-specific cholesterol regulation.
November 2025 in “PARIPEX-INDIAN JOURNAL OF RESEARCH” GFC is more effective than PRP for treating hair loss.
3 citations
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January 2025 in “动物学研究” This study used high-resolution imaging and genetic analysis to investigate hair density in the Dazu black goat, identifying key genes like GJA1 and GPRC5D involved in follicle development and maintenance, and highlighted their role in animal hair density regulation.
11 citations
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March 2008 in “Experimental Dermatology” This study identified a thiazolidine dione derivative as a potential inhibitor of 15-PGDH that may enhance prostaglandin activity in hair follicles, suggesting its use to support hair regrowth treatments.
9 citations
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September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.
1 citations
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April 2016 in “Journal of Investigative Dermatology” In this study, PGD2 treatment in keratinocytes increased testosterone production via reactive oxygen species, suggesting a potential role for the NRF2 pathway in androgenic alopecia treatment strategies.
69 citations
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December 2015 in “BMC plant biology” This study provides evidence that five Hyp-O-GALT genes are crucial for AGP galactosylation and that AGP glycans are vital for various aspects of plant growth and development.
6 citations
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December 2023 in “Journal of Molecular Cell Biology” In this study, Gsdma1/2/3 knockout mice showed reduced epidermal hyperplasia and inflammation when induced by PMA, which was attributed to decreased EGFR-Stat3/Akt signaling due to a decrease in related ligands.
25 citations
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January 2017 in “Steroids” This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.
October 2021 in “Scholarworks (University of Massachusetts Amherst)” This dissertation demonstrates that FERONIA regulates essential plant functions such as RAC/ROP signaling, pollen tube reception, cell wall integrity, and sugar signaling as a cell surface receptor kinase.
46 citations
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August 2020 in “International Journal of Genomics” This review examines over 271 candidate genes associated with economic traits in goats, highlighting their potential use in genetic markers and future breeding programs, and reports no new experimental results.
4 citations
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June 2021 in “Journal of Microbiology and Biotechnology” This study found that ginsenoside Rg4 enhanced hair-inductive properties of dermal papilla cells via the AKT/GSK3β/β-catenin pathway, suggesting its potential as a natural therapy for hair growth.