February 2025 in “Science Advances” This study demonstrates that Wnt signaling plays a crucial mechanoregulatory role in skin regeneration by influencing cellular responses to substrate rigidity, which promotes hair follicle regeneration in the wound-induced hair neogenesis model.
161 citations
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July 2003 in “ACM Transactions on Graphics” In this study, a new shading model for hair was developed that better matches real-life light scattering, thanks to detailed new measurements of hair fiber scattering not predicted by existing models.
This study introduced a new hair shading model that more accurately simulates light scattering on hair fibers, capturing effects not predicted by previous models.
13 citations
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September 2021 in “Communications Biology” This study introduces a five-modal microscopy technique that allows label-free, in vivo observation and quantitative analysis of various wound healing processes.
37 citations
,
June 2011 in “Journal of Cellular Biochemistry” In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.
23 citations
,
November 2001 in “Archives of Dermatology” This review discusses recent advances in the genetic understanding of inherited hair and nail disorders and reports no new clinical results.
22 citations
,
May 2021 in “Nature Communications” This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.
12 citations
,
July 2021 in “Scientific Reports” This study found that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, suggesting a novel signalling pathway in the skin.
3 citations
,
April 2025 in “Nature Communications” This study concluded that the GIANT brain atlas, which integrates genetic and neuroanatomical variations, provides a more accurate representation of brain structure than traditional neuroanatomical atlases, allowing for better exploration of genetic influences on the brain.
January 2024 in “Journal of Applied Pharmaceutical Science” This study identified procyanidin B2 and leucopelargonidin from Saraca asoca as potential inhibitors in PCOS by showing high binding energy scores against key enzymes involved in estrogen and testosterone biosynthesis.
45 citations
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September 2012 in “Life Sciences” This study observed that Aconiti Ciliare Tuber extract may promote hair growth in mice by activating the Wnt/β-catenin signaling pathway.
17 citations
,
July 2018 in “International Journal of Cosmetic Science” This study found that keratin-based particles were able to recover and enhance the mechanical properties and thermal stability of virgin and overbleached Asian hair, improving its strength and smoothness by around 40%, and demonstrated safety in human skin keratinocytes.
142 citations
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March 2019 in “Frontiers in Cellular Neuroscience” This review discusses the development and potential therapeutic applications of adenosine receptor agonists and positive allosteric modulators, noting that while many clinical trials have been unsuccessful, initial results for new compounds are promising.
58 citations
,
June 2018 in “Scientific reports” This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.
48 citations
,
May 2023 in “Nature Communications” In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.
44 citations
,
September 2019 in “The EMBO Journal” This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.
43 citations
,
November 2018 in “Nature Communications” This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
38 citations
,
July 2019 in “Nature Communications” This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.
30 citations
,
April 2021 in “The Journal of Sexual Medicine” This guideline provides recommendations for prescribing systemic testosterone to women with hypoactive sexual desire disorder, emphasizing safe dosing, monitoring, and the need for informed consent despite regulatory challenges.
27 citations
,
March 2019 in “PLoS ONE” This study suggests that Thyroxine (T4) may promote key features of human skin wound healing, such as re-epithelialization and angiogenesis, in an ex vivo model.
24 citations
,
November 2018 in “International Journal of Molecular Sciences” This review discusses ethosomes as lipid carriers that enhance drug penetration into deep skin layers and underscores the need for advanced research on their pharmaceutical applications, but it reports no clinical outcomes.
21 citations
,
August 2014 in “Gynecological Endocrinology” In this study, hs-CRP levels were not significantly associated with PCOS among Indian adolescent women, but showed a positive correlation with body mass index.
18 citations
,
September 2013 in “Technology” This study introduces a new multimodal imaging technology to visualize and quantify cell dynamics in natural skin over long durations, demonstrated in GFP bone marrow-transplanted mice, to study dynamic skin regeneration.
15 citations
,
December 2021 in “Nature Communications” In studying wild meerkats, researchers observed that matriarchs with high androgen levels during late gestation exhibited increased dominance and aggression, affecting both their behavior and their offspring's aggression.
15 citations
,
January 2019 in “Gynecological Endocrinology” This article discusses the need for a globally standardized protocol for epidemiologic studies of polycystic ovary syndrome to improve study comparability and public health policy.
14 citations
,
January 2012 in “Proteins” This study's molecular dynamics simulations suggest that electrostatic interactions mainly stabilize peptide binding to human hair keratin, with the protein's dielectric constant significantly affecting free energy calculations.
14 citations
,
April 2006 in “Expert Review of Dermatology” This review discusses therapeutic options for androgenetic alopecia, noting that while antiandrogen treatments prevent further hair loss and promote some regrowth, dramatic results are rare.
12 citations
,
September 2024 in “Frontiers in Immunology” This study found that metabolism-related genes significantly impact the prognosis and metastasis in breast cancer, and the development of prediction models may guide personalized therapeutic strategies.
11 citations
,
August 2020 in “Diabetes” This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.
6 citations
,
July 2016 in “Gynecological Endocrinology” This study found that women with PCOS have higher total PSA levels than controls, and the total PSA level correlates positively with testosterone and free androgen index.