77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
13 citations
,
March 2023 in “International Journal of Molecular Sciences” This study found that lower levels of Gas6 and sAxl were independently associated with a history of hair loss following COVID-19, which spontaneously resolved in most cases.
September 2021 in “Yearbook of pediatric endocrinology” This study found that in mice, chronic stress elevates corticosterone levels, which suppresses hair growth by keeping hair follicles in a prolonged resting phase.
130 citations
,
September 2018 in “Cell Reports” This study found that macrophages play a crucial role in nerve regeneration by regulating Schwann cell dynamics and remyelination, with Gas6 identified as a key factor in this process.
5 citations
,
October 2021 in “Signal Transduction and Targeted Therapy” In this study, structural and functional brain abnormalities specific to visuospatial and somatosensory processing networks were observed in patients with anorexia nervosa, highlighting a critical role for the precuneus.
October 2025 in “Advanced Materials” In this study, researchers developed ionizable coenzyme Q10-engineered lipid/fiber microplexes that restored mitochondrial-ribosomal function and enhanced mRNA translation in senescent cells, leading to increased hair follicle density and bone formation in mouse models compared to conventional lipid nanoparticles.
February 2023 in “Materials today bio” In this study, researchers developed a promising transdermal agent using Triton X-100-modified polyethyleneimine that successfully delivered genetic material to hair follicle cells in mice, potentially alleviating hair loss due to androgenetic alopecia by promoting cell proliferation and inhibiting apoptosis.
13 citations
,
March 2023 in “Cureus” This review identifies significant variability in insurance coverage for gender-affirming surgeries in the US, affecting equitable access to care for transgender individuals and suggesting a need for health policy reforms.
8 citations
,
April 2023 in “Cureus” This review explores stem cell applications for hair regrowth in alopecia, with no new clinical results, suggesting potential advantages over current FDA-approved treatments.
165 citations
,
June 2007 in “European Journal of Cell Biology” This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
116 citations
,
September 2020 in “Nature Communications” This study reports previously unrecognized cellular complexity in growing mouse incisors, suggesting species-specific differences in cell dynamics between mouse and human teeth related to growth and differentiation.
78 citations
,
October 2020 in “Experimental Dermatology” This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.
61 citations
,
December 2016 in “The EMBO Journal” This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.
35 citations
,
May 2021 in “Nature communications” This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.
30 citations
,
May 2019 in “Scientific Reports” This study found enhanced remyelination in the corpus callosum of late pregnant rats compared to virgin and postpartum rats, suggesting a pregnancy-associated promyelinating effect mediated, in part, by the GABA A receptor system.
26 citations
,
June 2018 in “The journal of immunology/The Journal of immunology” This study demonstrated that AIRE-deficient rats exhibit key symptoms of APECED, making them a relevant model for exploring potential treatments.
11 citations
,
March 2019 in “Journal of Medicinal Chemistry” This study reports that synthetic carbohydrate receptors effectively inhibit Zika virus infection in cell cultures by blocking early stages of viral entry.
10 citations
,
November 2022 in “Protein & Cell” In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.
10 citations
,
December 2021 in “Frontiers in cell and developmental biology” This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.
7 citations
,
October 2018 in “BMC genomics” This study reveals that β-catenin and retinoic acid are key regulators in the gene networks controlling the fate of skin appendages, such as scales and feathers.
4 citations
,
January 2026 in “Cell Discovery” This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.
4 citations
,
February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.
3 citations
,
September 2022 in “Frontiers in psychiatry” This study found that stress and its related symptoms were highly prevalent among university students in Egypt during the third wave of the COVID-19 pandemic, with most reporting negative coping strategies.
2 citations
,
March 2025 in “Archives of Dermatological Research” HEV light can harm or help skin and scalp, so safe exposure guidelines are needed.
2 citations
,
May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.
2 citations
,
December 2022 in “Scientific Data” This study used single-cell ATAC sequencing to map chromatin accessibility in developing mouse hair follicles, offering insights into the transcriptional regulation and epigenetic mechanisms underlying hair follicle development.
2 citations
,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.
1 citations
,
July 2025 in “Frontiers in Endocrinology” This review discusses the dual role of apoptotic vesicles in disease and therapy, emphasizing their potential in cancer treatment and tissue regeneration, but reports no new results.
1 citations
,
September 2023 in “eLife” This study found that TLR2 expression in hair follicle stem cells is crucial for hair follicle maintenance and regeneration, with TLR2-dependent activation potentially offering new therapeutic approaches for hair loss prevention through mechanisms involving immune pathways and CEP administration.
June 2026 in “The Journal of the Kyushu Dental Society” This study reviews the development of a mouse model using pyroxylin to induce localized hair growth and shorten the hair cycle's resting phase, suggesting it as a platform for evaluating hair growth treatments, though further research is needed for human application.