1 citations
,
October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
1 citations
,
January 2016 in “Elsevier eBooks” This chapter discusses the composition, biocompatibility, and production methods of biomaterials like collagen, chitin, and silk for dermal substitutes, focusing on preclinical and clinical research, but reports no new clinical results.
1 citations
,
November 2014 in “Elsevier eBooks” This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.
March 2026 in “IP Indian Journal of Clinical and Experimental Dermatology” This study found that female patients with acne had significantly higher insulin resistance compared to a control group without acne, suggesting that acne could serve as an early clinical marker of insulin resistance in women of reproductive age.
November 2025 in “Journal of Multidisciplinary Healthcare” This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
August 2025 in “Scientific Reports” This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.
This study observed that acne and hirsutism were common among women with PCOS, and found a significant link between higher BMI and the presence of acanthosis nigricans and hirsutism.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
271 citations
,
May 2019 in “Cells” This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.
204 citations
,
May 2014 in “The Journal of Sexual Medicine” This study concluded that current cross-sex hormone treatments for trans men and trans women are effective with a low risk of side effects in the short term, though they did observe specific clinical changes.
138 citations
,
May 2000 in “Maturitas” This review discusses the effects of estrogen on skin and reports no new clinical results; it highlights estrogen's potential benefits on skin thickness, collagen quality, and hair follicle life cycle.
137 citations
,
June 2005 in “Climacteric” This review indicates that estrogen loss during menopause significantly impacts skin health, while estrogen treatment may increase skin collagen, thickness, and elasticity, though effects on other skin characteristics are inconsistent.
120 citations
,
July 2005 in “Dermatologic surgery” This study found that topical niacinamide significantly improved the appearance of wrinkles, skin yellowing, and elasticity in aging facial skin over 12 weeks.
110 citations
,
October 2013 in “The Journal of Sexual Medicine” This study found that testosterone therapy in trans men increased facial and body hair growth while the prevalence and severity of acne peaked at 6 months but were primarily mild after long-term treatment.
87 citations
,
August 2017 in “Scientific Reports” This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.
79 citations
,
January 2015 in “Journal of Materials Chemistry B” This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.
76 citations
,
May 2007 in “Menopause International” This review discusses the relationship between estrogen deficiency and skin aging in postmenopausal women, noting potential benefits of estrogen use on skin collagen and elasticity, but reports no new clinical results.
65 citations
,
March 2018 in “Journal of Dermatological Science” This review discusses the role of mechanical forces in skin homeostasis and disease development, including their impact on conditions like keloids, androgenetic alopecia, and acral melanoma, and reports no clinical results; the authors propose modifying these forces as a potential therapeutic strategy.
65 citations
,
February 2017 in “Pflügers Archiv - European Journal of Physiology” This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.
59 citations
,
January 2010 in “Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review” This article reviews the medicinal properties of Semecarpus anacardium and its biologically active compounds, but it reports no new clinical results.
45 citations
,
January 2012 in “Experimental Dermatology” This study reveals that human hair follicles transition between active and dormant states stochastically, challenging the idea of a cyclical automaton controlling hair growth.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
42 citations
,
July 2014 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.
29 citations
,
September 2020 in “International Journal of Molecular Sciences” This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.
29 citations
,
April 2020 in “Biomolecules” The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.
29 citations
,
July 2012 in “Fertility and Sterility” This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
25 citations
,
May 2020 in “Aesthetic Surgery Journal” In this systematic review, tSVF-based therapy demonstrated favorable outcomes for various pathologies, including aged skin and osteoarthritis, with low incidence of adverse events, while highlighting the need for further research into optimal protocols and mechanisms of action.
25 citations
,
January 2001 in “Facial Plastic Surgery” This article reviews the history, methods, and complications of tissue expansion and serial excision for scar revision in the head and neck, and reports no new findings.
24 citations
,
November 2016 in “Molecular Medicine Reports” This study found that women with acne resistant to conventional treatments had significantly higher levels of testosterone, DHEA‑S, prolactin, and LH, suggesting potential underlying hormonal disorders.
22 citations
,
March 2018 in “American Journal of Clinical Dermatology” New acne treatments show promise as alternatives to traditional therapies.